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Stigma may also affect sero\u2010discordant couples where one partner is living with HIV, but the other is not. However, we know little about how HIV\u2010related stigma and couple relationship quality jointly affect depression and anxiety in both the individual and their partner. We analyzed dyadic data from 491 sero\u2010discordant pregnant couples in southwestern Kenya collected during 2019\u20132022 using Actor\u2010Partner Interdependence Model (APIM) methods. Controlling for relationship quality, HIV\u2010related stigma perceived by both women and men was detrimental to their own mental health as well as to their partner's mental health. High relationship quality was associated with better mental health of couple members, independent of stigma, but reporting high relationship quality did not significantly buffer the negative effect that stigma had on mental health. The partner effects of women's and men's relationship quality were sometimes in opposite directions: women's reports of higher relationship quality were negatively associated with men's depressive symptoms; however, men's reports of higher relationship quality were positively associated with higher depressive symptoms in women. These results suggest that interventions should support sero\u2010discordant couples to resist and reduce HIV\u2010related stigma as well as build positive couple relationships.<\/jats:p>","DOI":"10.1111\/aphw.70120","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:14:28Z","timestamp":1769667268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HIV\u2010related stigma, couple relationship quality, and mental health in sero\u2010discordant pregnant couples in Kenya"],"prefix":"10.1111","volume":"18","author":[{"given":"Asuman","family":"Buyukcan\u2010Tetik","sequence":"first","affiliation":[{"name":"Utrecht University  Utrecht the Netherlands"},{"name":"Sabanci University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turan Deniz","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Psychology, Health, and Technology, Faculty of Behavioural Management and Social Sciences University of Twente  Enschede the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Psychology Koc University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshmi","family":"Mukerji","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alabama at Birmingham  Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Owuor","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alabama at Birmingham  Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Hatcher","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Bukusi","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute  Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Kwena","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute  Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Helova","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alabama at Birmingham  Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Owengah","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute  Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynae","family":"Darbes","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Clinical Sciences, School of Nursing University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-6206","authenticated-orcid":false,"given":"Janet M.","family":"Turan","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alabama at Birmingham  Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.63.4.596"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2989\/AJAR.2009.8.2.1.853"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjhp.12738"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2024.117407"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001948"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1446.2007.00649.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0265407514541071"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15328007SEM0803_5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0146167200265007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2009.04.005"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2020.1724543"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16762-w"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2018.1510105"},{"key":"e_1_2_11_16_1","volume-title":"Dyadic data analysis","author":"Kenny D. 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