{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:12:13Z","timestamp":1773274333711,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T00:00:00Z","timestamp":1353628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,6]]},"abstract":"The purpose of our article is to describe the immunohistochemical findings of intrathyroidal epithelial thymoma\/carcinoma showing thymus\u2010like differentiation (ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content>) of the thyroid in detail, to clarify the difference between ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content> and thymic lymphoepithelioma\u2010like carcinoma (LELC<\/jats:styled-content>), and to discuss the pathogenesis of ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content>. We immunohistochemically examined five ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content> and eight LELC<\/jats:styled-content> cases. All of ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content> cases were strongly positive for CD5<\/jats:styled-content>, P63<\/jats:styled-content>, high\u2010molecular\u2010weight cytokeratin and B\u2010cell CLL\/lymphoma\u20102<\/jats:styled-content>. Carcinoembryonic antigen\u2010positive carcinoma cells were found in four ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content> cases. Neuroendocrine marker\u2010positive carcinoma cells were scattered in all cases. Immunohistochemical findings in thymic LELC<\/jats:styled-content> were essentially similar to those in ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content>, but the sensitivity was different. There is a possibility that ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content> and thymic LELC<\/jats:styled-content> are not the quite same disease entity. We think that ITET<\/jats:styled-content>\/CASTLE<\/jats:styled-content> is derived from ectopic thymus, but not related to solid cell nests.<\/jats:p>","DOI":"10.1111\/apm.12017","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T12:44:01Z","timestamp":1353674641000},"page":"523-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Intrathyroidal epithelial thymoma\/carcinoma showing thymus\u2010like differentiation; comparison with thymic lymphoepithelioma\u2010like carcinoma and a possibility of development from a multipotential stem cell"],"prefix":"10.1111","volume":"121","author":[{"given":"Mitsuyoshi","family":"Hirokawa","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kuma Hospital Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department 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