{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:49:39Z","timestamp":1791308979513,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Coagulase\u2010negative staphylococci (<jats:styled-content style=\"fixed-case\">CoNS<\/jats:styled-content>) are the leading cause of late\u2010onset sepsis (<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>) in neonates. Increasing resistance of <jats:styled-content style=\"fixed-case\">CoNS<\/jats:styled-content> to beta\u2010lactams and aminoglycosides has led to widespread use of vancomycin, which in turn may lead to resistance to vancomycin. Thus, combination therapy of <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content> has been advocated. We aimed to determine the interaction of oxacillin and gentamicin against <jats:styled-content style=\"fixed-case\">CoNS<\/jats:styled-content>. In 2005, 34 isolates of oxacillin\u2010 and gentamicin\u2010resistant <jats:styled-content style=\"fixed-case\">CoNS<\/jats:styled-content> were obtained from blood samples of neonates with <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>. Combination effect was tested using the checkerboard method, E\u2010test with the other antibiotic incorporated in the medium (E\u2010test\u20101) and two E\u2010test strips placed in a cross\u2010formation (E\u2010test\u20102). Of 34 isolates 61.8%, 53% and 73.5% revealed synergy or an additive effect when tested by the checkerboard method, E\u2010test\u20101 and E\u2010test\u20102, respectively. Results of all three tests were concordant for six (17.6%) isolates, four showing synergy, and two indifference. Our <jats:italic>in vitro<\/jats:italic> results support that combination therapy with penicillinase\u2010resistant penicillin and aminoglycoside can be an alternative to vancomycin.<\/jats:p>","DOI":"10.1111\/apm.12048","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T15:08:50Z","timestamp":1357571330000},"page":"859-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>In vitro<\/i> synergy of oxacillin and gentamicin against coagulase\u2010negative staphylococci from blood cultures of neonates with late\u2010onset sepsis"],"prefix":"10.1111","volume":"121","author":[{"given":"Tatjana","family":"Brilene","sequence":"first","affiliation":[{"name":"Department of Microbiology University of Tartu Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiie","family":"Soeorg","sequence":"additional","affiliation":[{"name":"Department of Microbiology 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