{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:54:17Z","timestamp":1790178857039,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>The aim of this work was to study the vascular endothelial growth factor <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) pathway and peritumoral brain edema (<jats:styled-content style=\"fixed-case\">PTBE<\/jats:styled-content>) through comparison of non\u2010angiomatous and angiomatous meningiomas. Meningiomas are common intracranial tumors, which often have <jats:styled-content style=\"fixed-case\">PTBE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> is an integral part of PTBE formation and angiogenesis, and the capillary\u2010rich angiomatous meningiomas are known for their PTBE. The <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> receptor <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20102 is responsible for the angiogenic effect of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> on endothelial cells, which is enhanced by the co\u2010receptor neuropilin\u20101. Forty non\u2010angiomatous, 22 angiomatous meningiomas, and 10 control tissue samples were collected for the study. Magnetic resonance images were available for 40 non\u2010angiomatous and 10 angiomatous meningiomas. Tissue sections were immunostained for <jats:styled-content style=\"fixed-case\">CD34<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MIB<\/jats:styled-content>\u20101, estrogen\u2010 and progesterone receptors. <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>, chemiluminescence, and <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> were used for <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VEGFR<\/jats:styled-content>\u20102, and neuropilin\u20101 protein and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> quantification. Angiomatous meningiomas had larger PTBE (695 vs 218\u00a0cm<jats:sup>3<\/jats:sup>, p\u00a0<jats:italic>=<\/jats:italic>\u00a00.0045) and longer capillary length (3614 vs 605\u00a0mm\/mm<jats:sup>3<\/jats:sup>, p\u00a0<jats:italic>&lt;<\/jats:italic>\u00a00.0001). <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A mRNA<\/jats:styled-content>, neuropilin\u20101 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">VEGFR<\/jats:styled-content>\u20102 protein levels were higher in angiomatous meningiomas independently of the capillary length (p\u00a0<jats:italic>&lt;<\/jats:italic>\u00a00.05). Neuropilin\u20101 protein levels were lower in angiomatous meningiomas (p\u00a0<jats:italic>&lt;<\/jats:italic>\u00a00.0001). The <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> pathway and tumor capillary length may be essential for <jats:styled-content style=\"fixed-case\">PTBE<\/jats:styled-content>\u2010formation in meningiomas. Further investigations of this pathway could lead to earlier therapy and targeted pharmacological treatment options.<\/jats:p>","DOI":"10.1111\/apm.12052","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T07:11:37Z","timestamp":1360566697000},"page":"1025-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Peritumoral brain edema in angiomatous supratentorial meningiomas: an investigation of the vascular endothelial growth factor <scp>A<\/scp> pathway"],"prefix":"10.1111","volume":"121","author":[{"given":"Damoun","family":"Nassehi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery"},{"name":"Neuropathology Laboratory"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars P.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Neuropathology 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