{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:36:28Z","timestamp":1766378188654},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>To investigate the rates of residual, recurrent and invasive disease after cervical conization in patients diagnosed with cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>) grades 2\/3.<\/jats:p><jats:p>A retrospective study was conducted with 274 patients undergoing cervical conization due to diagnosis of<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2\/3. Cervical conization was done through the Loop Electrosurgical Excision Procedure (<jats:styled-content style=\"fixed-case\">LEEP<\/jats:styled-content>) and Cold Knife Conization. Data related to personal, familial, gynecological, and obstetric antecedents, as well as surgical specimens margins were collected from medical records. The outcome after conization was evaluated, including the time of follow\u2010up and disease recurrence.<\/jats:p><jats:p>The outcome after conization was not associated with age of menarche (p\u00a0=\u00a00.920), age of the first sexual intercourse (p\u00a0=\u00a00.533), number of parturition (p\u00a0=\u00a00.063), number of sexual partners (p\u00a0=\u00a00.328), immunosuppression (p\u00a0=\u00a00.225), smoking habit (p\u00a0=\u00a00.193), and conization type (p\u00a0=\u00a00.198). However, the outcome presented a significant association with age (p\u00a0&lt;\u00a00.001), pregnancy numbers (p\u00a0=\u00a00.009), use of hormonal contraception methods (p\u00a0=\u00a00.016), menopause (p\u00a0=\u00a00.007), type of margins (p\u00a0=\u00a00.011), and cone histological results (p\u00a0=\u00a00.030).<\/jats:p><jats:p>The routine control of all patients who had undergone cervical conization is obligate, independently of surgical margins, due to the risk of disease recurrence; the older patients and those with<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 should have a more rigorous follow\u2010up.<\/jats:p>","DOI":"10.1111\/apm.12064","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T09:14:11Z","timestamp":1366708451000},"page":"1153-1161","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Post\u2010cervical conization outcomes in patients with high\u2010grade intraepithelial lesions"],"prefix":"10.1111","volume":"121","author":[{"given":"Renata B.","family":"Sim\u00f5es","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical Sciences College of Santa Casa of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana B.","family":"Campaner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical Sciences College of Santa Casa of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.07.045"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.11.046"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20516"},{"key":"e_1_2_6_5_1","first-page":"205","article-title":"New concepts on risk factors of HPV and novel screening strategies for cervical cancer precursors","volume":"29","author":"Syrj\u00e4nen K","year":"2008","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2007.03.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39363.471806.BE"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp089"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199304000-00018"},{"key":"e_1_2_6_11_1","first-page":"242","article-title":"High\u2010grade cervical intraepithelial neoplasia, human papillomavirus and factors connected with recurrence following surgical treatment","volume":"35","author":"Ramos MC","year":"2008","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00834.x"},{"key":"e_1_2_6_13_1","first-page":"83","article-title":"Laser vaporization in the management of CIN","volume":"31","author":"Vetrano G","year":"2010","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24794"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-10-11"},{"key":"e_1_2_6_16_1","first-page":"587","article-title":"Recurrent rates with cervical intraepithelial neoplasia having a negative surgical margin after the loop electrosurgical excision procedure in Thailand","volume":"10","author":"Suprasert P","year":"2009","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1298-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.04.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.11.015"},{"key":"e_1_2_6_20_1","first-page":"637","article-title":"Positive margin prevalence and risk factors with cervical specimens obtained from loop electrosurgical excision procedures and cold knife conization","volume":"10","author":"Panna S","year":"2009","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3760\/cma.j.issn.0366-6999.2009.04.002","article-title":"Predictors and clinical significance of the positive cone margin in cervical intraepithelial neoplasia III patients","volume":"122","author":"Sun XG","year":"2009","journal-title":"Chin Med J"},{"key":"e_1_2_6_22_1","first-page":"33","article-title":"Cold knife conization vs LEEP. 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