{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:04:33Z","timestamp":1791338673221,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Burkitt lymphoma (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) occurs at all ages, but the patterns of Epstein\u2013Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) positivity in relation to human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>), immunoprofiles and age have not been fully explored. <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> tissues from residual tissue repositories, and two academic centers in the United States were examined by expert hematopathologists for morphology, immunohistochemistry, <jats:styled-content style=\"fixed-case\"><jats:italic>MY<\/jats:italic>C<\/jats:styled-content> rearrangement, <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010encoded <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">EBER<\/jats:styled-content>), and diagnosed according to the 2008 <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> lymphoma classification. Analysis was done using frequency tables, Chi\u2010squared statistics, and Student's <jats:italic>t<\/jats:italic>\u2010test. Of 117 cases examined, 91 were confirmed as <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>. The age distribution was 26%, 15%, 19%, and 29% for 0\u201319, 20\u201334, 35\u201359, 60+ years, and missing in 11%. <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> rearrangement was found in 89% and <jats:styled-content style=\"fixed-case\">EBER<\/jats:styled-content> positivity in 29% of 82 cases with results. <jats:styled-content style=\"fixed-case\">EBER<\/jats:styled-content> positivity varied with age (from 13% in age group 0\u201319 to 55% in age group 20\u201334, and fell to 25% in age group 60+ years, p\u00a0=\u00a00.08); with race (56% in Blacks\/Hispanics vs 21% in Whites\/Asians\/Pacific Islanders, p\u00a0=\u00a00.006); and by <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status (64% in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> positive vs 22% in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> negative cases, p\u00a0=\u00a00.03). <jats:styled-content style=\"fixed-case\">EBER<\/jats:styled-content> positivity was demonstrated in about one\u2010third of tumors and it was strongly associated with race and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status, and marginally with age\u2010group.<\/jats:p>","DOI":"10.1111\/apm.12078","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T09:14:23Z","timestamp":1366708463000},"page":"5-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Epstein\u2013Barr virus patterns in <scp>US<\/scp> Burkitt lymphoma tumors from the <scp>SEER<\/scp> residual tissue repository during 1979\u20132009"],"prefix":"10.1111","volume":"122","author":[{"given":"Sam M.","family":"Mbulaiteye","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics Department of Health and Human Services National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheeja T.","family":"Pullarkat","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine University of California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat N.","family":"Nathwani","sequence":"additional","affiliation":[{"name":"Cedars Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence M.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Clarient, Inc. 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