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We evaluated the status of several immunohistochemical markers with histopathologic parameters in various grades of meningioma.Eighty\u2010eight meningioma specimens were examined immunohistochemically to determine the status of Ki\u201067, cyclin D1, epidermal growth factor receptor (<jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>), cyclooxygenase\u20102 (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102), vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>), and bcl\u20102. Several clinical and pathological parameters were investigated.Forty\u2010nine Grade I, 33 Grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and 6 Grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> meningiomas were observed. <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> and Ki\u201067 expression was correlated with higher tumor grade. The association between grade and other immunohistochemical markers expression was not significant. A correlation was observed between <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expression and invasiveness to the brain or adjacent soft tissue. Tumor recurrence was correlated with brain or adjacent soft tissue invasion. We also observed a relationship between <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> level and <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expression, and they were both correlated with necrosis.Immunohistochemical evaluation of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> COX<\/jats:styled-content>\u20102, and Ki\u201067 expression can provide information regarding the behavior of meningiomas, particularly for cases in which histological grading is not straightforward.<\/jats:p>","DOI":"10.1111\/apm.12079","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T05:33:27Z","timestamp":1371015207000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Significance of <scp>COX<\/scp>\u20102 and <scp>VEGF<\/scp> expression in histopathologic grading and 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