{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T16:15:30Z","timestamp":1764519330494},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Since the discovery of Merkel cell polyomavirus and its causative association with Merkel cell carcinoma (MCC), six human polyomaviruses (<jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yVs) have been identified that, so far, lack any disease association, which include the human polyomaviruses (<jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV) 6, 7, 9, 10 and 12 as well as the Saint Louis polyomavirus (<jats:styled-content style=\"fixed-case\">STLP<\/jats:styled-content>yV). <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> studies revealed that <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV6 and <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV7 are shed from the skin of healthy subjects and of patients suffering from various skin tumours. <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV6, 7 and 9 were sporadically detected in body fluids and excretions of immunocompromised patients and healthy subjects. <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV10 was identified in papillomavirus\u2010induced anal condylomas, and variants of <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV10, named <jats:styled-content style=\"fixed-case\">MWP<\/jats:styled-content>yV and MX polyomavirus (human) (<jats:styled-content style=\"fixed-case\">MXP<\/jats:styled-content>yV), as well as <jats:styled-content style=\"fixed-case\">STLP<\/jats:styled-content>yV were detected in faeces of diarrheal and healthy children. <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV12 was discovered in organs of the digestive tract of patients suffering from various malignant diseases. Serological studies using capsomer\u2010based or virus\u2010like particle (VLP)\u2010based enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) revealed that <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV6, 7, 9 and 12 are circulating in the human population. As all other <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yVs, the novel polyomaviruses encode small and large T antigens and thus are potentially oncogenic. However, several studies have revealed a lack of association of <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yV6, 7 and 9 with numerous human tumours. In the future, it will be important to unravel the cell types and body compartments of the novel <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>yVs\u2032 reservoir and to search for possible associations with cancer and non\u2010malignant diseases.<\/jats:p>","DOI":"10.1111\/apm.12104","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T12:02:38Z","timestamp":1368014558000},"page":"783-795","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The novel human polyomaviruses <scp>HPyV<\/scp>6, 7, 9 and beyond"],"prefix":"10.1111","volume":"121","author":[{"given":"Bernhard","family":"Ehlers","sequence":"first","affiliation":[{"name":"Division 12 \u2018Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients\u2019 Robert Koch\u2010Institute Berlin 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