{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T21:54:51Z","timestamp":1722030891603},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Available data correlating symptoms of colon cancer patients with the severity of the disease are very limited. In a population\u2010based setting, we correlated information on symptoms of colon cancer patients with several pathological tumor parameters and survival. Information on all patients diagnosed with colon cancer in Iceland in 1995\u20132004 for this retrospective, population\u2010based study was obtained from the Icelandic Cancer Registry. Information on symptoms of patients and blood hemoglobin was collected from patients' files. Pathological parameters were obtained from a previously performed standardized tumor review. A total of 768 patients entered this study; the median age was 73\u00a0years. Tumors in patients presenting at diagnosis with visible blood in stools were significantly more likely to be of lower grade, having pushing border, conspicuous peritumoral lymphocytic infiltration, and lower frequency of vessel invasion. Patients with abdominal pain and anemia were significantly more likely to have vessel invasion. Logistic regression showed that visible blood in stools was significantly associated with protecting pathological factors (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> range 0.38\u20130.83, p\u00a0&lt;\u00a00.05). Tumors in patients presenting with abdominal pain were strongly associated with infiltrative margin and scarce peritumoral lymphocytic infiltration (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.95; 2.18 respectively, p\u00a0&lt;\u00a00.05). Changes in bowel habits were strongly associated with vessel invasion (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.03, p\u00a0&lt;\u00a00.05). Cox regression showed that blood in stools predicted survival (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.54). In conclusion, visible blood in stools correlates significantly with all the beneficial pathological parameters analyzed and with better survival of patients. Anemia, general symptoms, changes in bowel habits, acute symptoms, and abdominal pain correlate with more aggressive tumor characteristics and adverse outcome for patients.<\/jats:p>","DOI":"10.1111\/apm.12109","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T12:08:09Z","timestamp":1368014889000},"page":"901-907","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Colon cancer: association of histopathological parameters and patients' survival with clinical presentation"],"prefix":"10.1111","volume":"121","author":[{"given":"Kristin K.","family":"Alexiusdottir","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"Oncology Research Center Landspitali \u2010 University Hospital Reykjavik Iceland"},{"name":"The Icelandic Cancer Registry Icelandic Cancer Society Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petur","family":"Snaebjornsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"Department of Pathology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laufey","family":"Tryggvadottir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"The Icelandic Cancer Registry Icelandic Cancer Society Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larus","family":"Jonasson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"Department of Pathology Landspitali \u2010 University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elinborg J.","family":"Olafsdottir","sequence":"additional","affiliation":[{"name":"The Icelandic Cancer Registry Icelandic Cancer Society Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar Stefan","family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"Department of Gastroenterology Landspitali \u2010 University Hospital Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pall Helgi","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"Department of Surgery Landspitali \u2010 University Hospital Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon G.","family":"Jonasson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"The Icelandic Cancer Registry Icelandic Cancer Society Reykjavik Iceland"},{"name":"Department of Pathology Landspitali \u2010 University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Cancer Incidence in Five Continents","author":"Curado MP","year":"2007"},{"key":"e_1_2_7_3_1","volume-title":"Cancer in Iceland. 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