{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T06:23:31Z","timestamp":1743661411965},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>The knowledge of systemic inflammation and local cytokine expression in porcine endocarditis models is limited, though it could provide valuable information about the pathogenesis and comparability to human endocarditis. Analyses of bacteriology and hematology were performed on blood samples from pigs with non\u2010bacterial thrombotic endocarditis (<jats:styled-content style=\"fixed-case\">NBTE<\/jats:styled-content>, n\u00a0=\u00a011), <jats:italic>Staphylococcus aureus<\/jats:italic> infective endocarditis (<jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>, n\u00a0=\u00a02), animals with <jats:italic>S. aureus<\/jats:italic> sepsis without endocarditis (n\u00a0=\u00a02) and controls (n\u00a0=\u00a02). Furthermore, immunohistochemistry was used to examine the local expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108. Bacterial blood cultures were continuously positive in <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> pigs from inoculation to euthanasia, and negative in all other pigs at all times. The total white blood cell counts and total neutrophil counts were massively elevated in pigs with <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>. Local <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 expression in <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> pigs were moderate to high, and high, respectively. In addition, slight local expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 was present in some <jats:styled-content style=\"fixed-case\">NBTE<\/jats:styled-content> pigs. In the <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> model, both the systemic inflammatory response and the high local expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 were comparable to the human disease. Furthermore, the results indicate <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 as important contributors in the endocarditis pathogenesis.<\/jats:p>","DOI":"10.1111\/apm.12145","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T19:32:12Z","timestamp":1374694332000},"page":"292-300","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Systemic inflammatory response and local cytokine expression in porcine models of endocarditis"],"prefix":"10.1111","volume":"122","author":[{"given":"Johanna G.","family":"Christiansen","sequence":"first","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Health and Medical Sciences University of Copenhagen Frederiksberg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik 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