{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:06:51Z","timestamp":1788336411851,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:00:00Z","timestamp":1378425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Recently, miR\u2010155 has been implicated in cutaneous T\u2010cell lymphoma (CTCL). Thus, elevated levels of miR\u2010155 were observed in skin lesions from CTCL patients as judged from <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> and micro\u2010array analysis and aberrant, high miR\u2010155 expression was associated with severe disease. Moreover, miR\u2010155 promoted proliferation of malignant T cells <jats:italic>in vitro<\/jats:italic>. Little is, however, known about which cell types express miR\u2010155 <jats:italic>in vivo<\/jats:italic> in CTCL skin lesions. Here, we study miR\u2010155 expression using <jats:italic>in situ<\/jats:italic> hybridization (ISH) with a miR\u2010155 probe, a negative control (scrambled), and a miR\u2010126 probe as a positive control in nine patients with mycosis fungoides, the most frequent subtype of CTCL. We provide evidence that both malignant and non\u2010malignant T cells stain weakly to moderately positive with the miR\u2010155 probe, but generally negative with the miR\u2010126 and negative control probes. Reversely, endothelial cells stain positive for miR\u2010126 and negative for miR\u2010155 and the control probe. Solitary T cells with a malignant morphology display brighter staining with the miR\u2010155 probe. Taken together, our findings suggest that both malignant and non\u2010malignant T cells express miR\u2010155 <jats:italic>in situ<\/jats:italic> in CTCL. Moreover, they indicate heterogeneity in miR\u2010155 expression among malignant T cells.<\/jats:p>","DOI":"10.1111\/apm.12162","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T06:01:57Z","timestamp":1378447317000},"page":"1020-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Expression of miR\u2010155 and miR\u2010126 <i>in situ<\/i> in cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"121","author":[{"given":"Katharina L.","family":"Kopp","sequence":"first","affiliation":[{"name":"Department of International Health, Immunology and Microbiology (UoC) Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Ralfkiaer","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology (UoC) Copenhagen 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