{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:19:49Z","timestamp":1791512389720,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Atorvastatin, a hydroxymethylglutaryl\u2010CoA reductase inhibitor, and endothelin\u20101 (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u20101) receptor antagonist have been separately indicated to ameliorate disease progression in atherosclerosis. However, no study has evaluated the effect of their combination on atherosclerosis. The objective of the current study was to evaluate the direct <jats:italic>in vivo<\/jats:italic> effects of a combination regimen of atorvastatin and <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u20101 receptor antagonist on male <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand white rabbit models of atherosclerosis (injury\u2010induced). Thirty\u2010two atherosclerotic rabbits were divided into four experimental groups: (a) <jats:italic>injury group<\/jats:italic> \u2013 fed high\u2010fat diet; (b) <jats:italic><jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u20101 receptor antagonist preventive group<\/jats:italic> \u2013 fed high\u2010fat diet, but with intragastric administration of the <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u20101 receptor antagonist, darusentan; (c) <jats:italic>combined preventive group<\/jats:italic> \u2013 fed high\u2010fat diet, but with intragastric administration of both darusentan and atorvastatin; and (d) <jats:italic>treatment group<\/jats:italic> \u2013 fed high\u2010fat diet for the first 8\u00a0weeks, followed by normal diet and intragastric administration of both darusentan and atorvastatin up to 16\u00a0weeks. A further eight non\u2010atherosclerotic rabbits were fed normal diet and classified as the <jats:italic>control group<\/jats:italic>. At the end of 8 and 16\u00a0weeks, compared with the <jats:italic>injury group<\/jats:italic>, the <jats:italic>combined preventive group<\/jats:italic> had significant reduction in both the concentration of serum lipids and inflammatory factors and atherosclerosis formation, indicative of a multifaceted anti\u2010atherosclerotic impact. The relative area of atherosclerotic lesions in the <jats:italic>injury group<\/jats:italic> (30.84%) was significantly higher than the <jats:italic>control group<\/jats:italic> (4.62%; p\u00a0&lt;\u00a00.05). The <jats:italic>combined preventive group<\/jats:italic> showed a significantly robust effect on lowering serum lipid, inflammatory cytokines, and maintained homeostatic balance of free radicals, and important downstream effectors like <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u20101 and matrixmetalloproteinase\u20109. Our data show that atorvastatin and <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u20101 receptor antagonist co\u2010administration may decrease lipid levels, stabilize plaques and relieve vascular inflammation. By reducing the plaque burden, this regimen may minimize the risk of atherosclerotic plaque rupture or arterial occlusion.<\/jats:p>","DOI":"10.1111\/apm.12185","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T06:08:44Z","timestamp":1383026924000},"page":"556-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inhibitory effect of co\u2010administration of atorvastatin and endothelin\u20101 receptor antagonist on the progression of atherosclerosis in rabbit"],"prefix":"10.1111","volume":"122","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology Chinese PLA General Hospital Beijing China"},{"name":"Department of Emergency The Military General Hospital of Beijing PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department 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