{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:01:04Z","timestamp":1791115264905,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ALF"},{"name":"Kempe Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    Hidradenitis suppurativa (acne inverse) (\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    ) is a chronic skin disease primarily affecting hair follicles. The aetiology of\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    is unknown, but infection is believed to play some role. This retrospective study investigated the microbial colonization directly in skin appendices in\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    skin samples. Archival samples from 27 patients with\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    were screened by immunofluorescence labelling with monoclonal and polyclonal antibodies against Gram\u2010positive bacteria,\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    and\n                    <jats:italic>Propionibacterium granulosum<\/jats:italic>\n                    . Fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization was used for further species identification of\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    spp. Overall, 17 patients (63%) were found positive for bacterial colonization. Of these, 15 showed colonization in hair follicles and\/or sinus tracts. The most commonly identified bacteria were\n                    <jats:styled-content style=\"fixed-case\">DAPI<\/jats:styled-content>\n                    labelled coccoids that were seen in 71% of the positive patients in the form of biofilms and microcolonies.\n                    <jats:italic>P. acnes<\/jats:italic>\n                    was found as biofilms in hair follicles of two patients.\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and coagulase\u2010negative staphylococci were not detected in any sample. The results of this study indicate a common bacterial presence in\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    skin lesions. Bacterial biofilms are not uncommon and their pathogenic role needs further evaluation.\n                  <\/jats:p>","DOI":"10.1111\/apm.12220","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T02:42:54Z","timestamp":1391049774000},"page":"804-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Microbiology of hidradenitis suppurativa (acne inversa): a histological study of 27 patients"],"prefix":"10.1111","volume":"122","author":[{"given":"Anika C.","family":"Jahns","sequence":"first","affiliation":[{"name":"Department of Medical Biosciences\/Pathology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Killasli","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Dermatology Department of Medicine Karolinska Institute Huddinge Stockholm 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