{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:54:18Z","timestamp":1773341658271,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:00:00Z","timestamp":1391126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Fund of Guangdong","award":["S2013040016966"],"award-info":[{"award-number":["S2013040016966"]}]},{"name":"the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University","award":["2011KF03"],"award-info":[{"award-number":["2011KF03"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>) is the leading cause of blindness in preterm infants. In this study, we investigated the cytokine levels in cord blood of normal preterm neonates and preterm infants developed <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>. Serum levels of 10 cytokines in umbilical cord blood were measured by multiplex protein arrays from 62 healthy preterm neonates and 30 preterm neonate cases who developed <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> at later stage. Results showed that serum levels of cytokines including interleukin 7 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107), monocyte chemotactic protein\u20101 (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101), macrophage inflammatory protein 1 alpha (<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b1), and macrophage inflammatory protein 1 beta (<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b2) were significantly increased in cases who developed <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> than in healthy preterm neonates (3.5\u2010fold, 3.2\u2010fold, 3.4\u2010fold, and 2.1\u2010fold, respectively), whereas levels of these four cytokines did not reveal any significant differences between healthy preterm infants and normal infants. When comparing the expression of cytokines in <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> patients with different clinical parameters, <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> cases whose gestational age at delivery earlier than 29.0\u00a0weeks demonstrated increased levels of <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b2 than those later than 29.0\u00a0weeks (p\u00a0&lt;\u00a00.05). Also, <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> cases with birth weight less than 1.28\u00a0kg revealed significantly higher level of <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b2 than those who were heavier than 1.28\u00a0kg (p\u00a0&lt;\u00a00.05). These data indicated that levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107, <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b1, and <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b2 were associated with increased risk of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>, in which <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b2 may be further correlated with the severity of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.12223","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T06:57:03Z","timestamp":1391151423000},"page":"818-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Serum concentrations of cytokines in infants with retinopathy of prematurity"],"prefix":"10.1111","volume":"122","author":[{"given":"Honghua","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology General Hospital of Guangzhou Military Command of PLA Guangzhou China"},{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Kunming Medical College Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology General Hospital of Guangzhou Military Command of PLA Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianghong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology General Hospital of Guangzhou Military Command of PLA Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology General Hospital of Guangzhou Military Command of PLA Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibo","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.3.540"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.11.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"e_1_2_7_5_1","first-page":"262","article-title":"Fibroblastic overgrowth of persistent tunica vasculosa lentis in infants born prematurely: II. 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