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The aim of this study was to investigate the clinical and histopathological features in these tumours associated with patient survival. This enables evaluation of current grading guidelines and practice. In this study, 196 primary, intracranial, and consecutively treated patients from one institution were included. All histological sections were reviewed. Survival data were controlled with the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orwegian <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ause of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>eath <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egistry. Falcine location, sheet\u2010like growth, frequent mitoses, subtotal resection grade, and absence of psammoma bodies were strong prognostic factors. Of these factors, the latter two were statistically significantly associated with decreased time to recurrence in multivariate analyses. The <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 2000 and 2007 classifications were associated with decreased time to recurrence. However, the grading criteria suggested by Ho et\u00a0al. (2002) and in this study achieved stronger prognostic values. Easily recognizable histopathological criteria are essential in tumour grading. We suggest that any two of the following three variables can be used to recognize atypical (grade II) meningiomas: absence of psammoma bodies, presence of necrosis, and\/or \u22654 mitoses per 10 high power fields.<\/jats:p>","DOI":"10.1111\/apm.12248","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T06:33:19Z","timestamp":1396506799000},"page":"856-866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Histopathology and prognosis in human meningiomas"],"prefix":"10.1111","volume":"122","author":[{"given":"Thomas","family":"Backer\u2010Gr\u00f8ndahl","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Children's and Women's Health Faculty of Medicine Norwegian University of Science and Technology Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rnar H.","family":"Moen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Children's and Women's Health Faculty of Medicine Norwegian University of Science and Technology Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein H.","family":"Sundstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Olavs Hospital University Hospital of Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre H.","family":"Torp","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Children's and Women's Health Faculty of Medicine Norwegian University of Science and Technology Norway"},{"name":"Department of Pathology and Medical Genetics St. Olavs Hospital University Hospital of Trondheim Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,3]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"ii1","article-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States 2006\u20132010","volume":"15","author":"Ostrom QT","journal-title":"Neuro\u2010Oncol 2013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21255"},{"key":"e_1_2_8_4_1","first-page":"163","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Perry A","year":"2007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-009-0251-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(86)90233-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199712000-00008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3181eb95b7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25591"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10351"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06982-6.00010-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC\/2008\/24\/5\/E3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2004.00621.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9<2046::AID-CNCR23>3.0.CO;2-M"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0343-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.077974"},{"key":"e_1_2_8_17_1","unstructured":"Statistics Norway.SSB: Population by sex age and municipality 1 January 2011;Oslo:Statistics Norway."},{"key":"e_1_2_8_18_1","volume-title":"WHO Handbook for Reporting Results of Cancer Treatment","year":"1979"},{"key":"e_1_2_8_19_1","unstructured":"Norwegian Institute of Public Health. 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