{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:11:07Z","timestamp":1780049467091,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u00ef\u00bf\u00bdrebro research committee","award":["OLL-135771"],"award-info":[{"award-number":["OLL-135771"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>The anterior nares have been regarded as the major carriage site of <jats:italic>Staphylococcus aureus<\/jats:italic>. From here, the organism can spread to other parts of the body where it might act as harmless commensal or cause mild to severe infections. Nasal sinuses are normally sterile, but in patients with chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>), the finding of <jats:italic>S.\u00a0aureus<\/jats:italic> in maxillary sinus cultures is common. Isolates were obtained from the nares and maxillary sinus of patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and the nares of healthy controls. A significantly higher frequency of <jats:italic>S.\u00a0aureus<\/jats:italic> was found in nares samples from patients (24\/42) compared to controls (16\/57) (p\u00a0=\u00a00.004). There is no consensus regarding whether <jats:italic>S.\u00a0aureus<\/jats:italic> is a relevant pathogen in <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>. A <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> microarray was used to investigate the prevalence of <jats:italic>S.\u00a0aureus<\/jats:italic> virulence genes with focus on staphylococcal enterotoxins, toxic shock syndrome toxin\u20101, <jats:italic>agr<\/jats:italic> types, and cell wall\u2010associated proteins. The genotyping of <jats:italic>S.\u00a0aureus<\/jats:italic> isolates revealed only small and non\u2010significant differences in gene prevalence between isolates collected from patients with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and those collected from healthy nasal carriers. This study provides an increased knowledge of the genetic pattern of virulence genes among <jats:italic>S.\u00a0aureus<\/jats:italic> collected in <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.12299","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T14:45:00Z","timestamp":1407336300000},"page":"37-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Molecular characteristics of <i>Staphylococcus aureus<\/i> associated with chronic rhinosinusitis"],"prefix":"10.1111","volume":"123","author":[{"given":"Ulrica","family":"Thunberg","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svante","family":"Hugosson","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Monecke","sequence":"additional","affiliation":[{"name":"Alere Technologies GmbH Jena Germany"},{"name":"Institute for Medical Microbiology and Hygiene Technical University of Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Ehricht","sequence":"additional","affiliation":[{"name":"Alere Technologies GmbH Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"S\u00f6derquist","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Laboratory Medicine Clinical Microbiology \u00d6rebro University Hospital \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.3.505"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70295-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810701107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(00)00377-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-003-0065-y"},{"key":"e_1_2_7_7_1","first-page":"305","article-title":"Chronic rhinonsinusitis and nasal polyposis: the etiopathogenesis revealed?","volume":"70","author":"Van Cauwenberge P","year":"2008","journal-title":"Verh K Acad Geneeskd Belg"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<1021::AID-IMMU1021>3.0.CO;2-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282f4178f"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12239"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12230"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02709.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00146.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500459231"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2012.02559.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3181ecd8ae"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00830.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn435"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017936"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.01986.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(99)01609-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0752-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009525"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21400"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240301700601"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.79"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.4.1434-1439.2003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2008.09.012"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200502000-00010"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07877-7"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70238-4"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/313461"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3228"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01798.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3367"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890250037007"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00184109"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04872.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1049-x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-5-28"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12299","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:06:04Z","timestamp":1695575164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/apm.12299"],"URL":"https:\/\/doi.org\/10.1111\/apm.12299","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]},"assertion":[{"value":"2014-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}