{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:43:14Z","timestamp":1758818594985},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Osteosarcomas arising in the epiphysis are extremely rare and easily missed in the diagnostic consideration of epiphyseal tumors. It is the purpose of this study to delineate the clinical pathological characteristics of \u2018epiphyseal osteosarcoma\u2019 under the definition of \u2018a solitary long bone osteosarcoma <jats:italic>radiographically<\/jats:italic> considered an epiphyseal tumor for which the main radiologic differential diagnosis would encompass giant cell tumor, chondroblastoma and clear cell chondrosarcoma\u2019.<\/jats:p><jats:p>Four such cases with unusual histopathology were retrieved among 110 cases of osteosarcoma. Their clinical, radiological and pathological features, together with all 10 reported cases, were analyzed.<\/jats:p><jats:p>The radiographic diagnoses of our four cases include two giant cell tumors, one chondroblastoma and one clear cell chondrosarcoma but turn out to be fibroblastic, giant cell rich, telangiectatic and epithelioid variant of epiphyseal osteosarcoma. Including our patients, the 14 reported epiphyseal osteosarcomas comprise 8 males and 6 females, the age at presentation ranges from 11 to 39\u00a0years, two\u2010third in the second decade, 71.4% affect the femur. Due to their epiphyseal locations, many carry benign radiological diagnoses notably giant cell tumor and chondroblastoma.<\/jats:p><jats:p>Epiphyseal osteosarcomas may not only masquerade as benign radiological bony lesions but also assume many histological patterns; orthopedic surgeons, radiologists and pathologists should be aware of such possibility. Their behavior and prognosis are dictated by the histologic types, grading and staging rather than location.<\/jats:p>","DOI":"10.1111\/apm.12300","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T07:09:36Z","timestamp":1411369776000},"page":"9-17","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review"],"prefix":"10.1111","volume":"123","author":[{"given":"Louis Tsun Cheung","family":"Chow","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Kwok Chuen","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Prince of Wales Hospital Shatin Hong 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