{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:38:59Z","timestamp":1790566739762,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Calcifying fibrous tumor is a rare benign mass lesion characterized by bland spindle cells embedded in abundant collagenous matrix, interspersed dystrophic or psammomatous calcifications, and lymphoplasmacytic infiltrate. It shares several clinical and morphologic features with IgG4\u2010related disease, a newly recognized fibroinflammatory disorder. Characteristic histologic features of IgG4\u2010related lesions include dense fibrosis and abundant lymphoplasmacytic infiltrate, similar to calcifying fibrous tumor. They contain high numbers of IgG4\u2010positive plasma cells in the tissue. Patients also often have elevated serum IgG4 levels. We report the case of a patient with an ileal calcifying fibrous tumor that contained 69 IgG4\u2010positive plasma cells per high\u2010power field and an IgG4\u2010to\u2010IgG ratio of 56% in lesional plasma cells. The patient's serum IgG4 level was 185\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>, more than double the normal value. Altogether, these features suggest that calcifying fibrous tumor could be an unrecognized lesion of IgG4\u2010related disease.<\/jats:p>","DOI":"10.1111\/apm.12302","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T07:16:22Z","timestamp":1411370182000},"page":"72-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Calcifying fibrous tumor: an unrecognized IgG4\u2014related disease?"],"prefix":"10.1111","volume":"123","author":[{"given":"Brent K.","family":"Larson","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Balzer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Los Angeles CA 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