{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:50:17Z","timestamp":1787615417872,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>), a threat for hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) recipients, is still one of the most common viral pathogens that affect these patients with a reported incidence ranging between 17% and 50% in the post transplantation period. Valganciclovir (V\u2010<jats:styled-content style=\"fixed-case\">GCV<\/jats:styled-content>), a valine ester pro\u2010drug of <jats:styled-content style=\"fixed-case\">GCV<\/jats:styled-content> orally administrable, has recently shown great activity against <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infections, but there are no reports of its clinical efficacy against <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>. We here report a case history of a patient with positive serologic test for <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>, who underwent allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and developed an atypical varicella\u2010like illness. First\u2010line therapy with foscarnet had to be discontinued due rapid development of renal impairment (creatinine: 2.60\u00a0mg\/dL, urea: 130.6\u00a0mg\/dL) and therefore was switched to V\u2010<jats:styled-content style=\"fixed-case\">GCV<\/jats:styled-content>. The renal impairment and skin lesions of the patient fully recovered after few days of therapy, even though the patient had complete lymphocyte depletion. This is the first case of a patient with chickenpox\u2010like illness treated successfully with V\u2010<jats:styled-content style=\"fixed-case\">GCV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.12303","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T14:45:15Z","timestamp":1407336315000},"page":"77-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Complete remission of <scp>VZV<\/scp> reactivation treated with valganciclovir in a patient with total lymphocyte depletion and acute kidney injury after allogeneic bone marrow transplantation"],"prefix":"10.1111","volume":"123","author":[{"given":"Natalia","family":"Maximova","sequence":"first","affiliation":[{"name":"Institute for Maternal and Child Health\u2010IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pizzol","family":"Antonio","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2010IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Granzotto","family":"Marilena","sequence":"additional","affiliation":[{"name":"Laboratory Department A.O.U Ospedali Riuniti Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rovere","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2010IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tamaro","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2010IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"},{"name":"Department of Pediatrics University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.9.5236-5242.1995"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.2.965-974.1998"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6143.2003.00287.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3624"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.5.840"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609053351007"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702190"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(00)70051-6"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02528.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.06.019"},{"key":"e_1_2_4_12_1","volume-title":"COMPLICATIONS Viral infections ESH\u2010EBMT training course","author":"Lion T","year":"2014"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12133"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.01.067"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3786"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03112.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.08.023"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1179\/1973947813Y.0000000082"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-012-1087-9"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:06:11Z","timestamp":1695575171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/apm.12303"],"URL":"https:\/\/doi.org\/10.1111\/apm.12303","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]},"assertion":[{"value":"2014-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}