{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:33:04Z","timestamp":1761129184275,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171648"],"award-info":[{"award-number":["81171648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>This study aims to characterize the clinical features of community\u2010acquired methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content>) infections in Chinese neonates, as well as the molecular characteristics and expression of key virulence genes of isolates. Clinical information and molecular characteristics of 130 cases were analyzed. Up to 83.8% patients were affected with late\u2010onset infection. Cesarean delivery was the main delivery route, accounting for 74.6% of the total deliveries. Pneumonia (69, 53.1%) was the most common infection. A total of 38 patients (29.2%) suffered from complications. Moreover, 35 cases (26.9%) were invasive infections, among which 88.6% involved multiple organs and 45.7% suffered from complications. Cesarean section and premature birth were the risk factors for invasive <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content> infection. <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>59\u2010<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>mec<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>a\u2010t437 (54, 41.5%) was the most predominant <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content> clone. The <jats:italic>hla<\/jats:italic> expression in the <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>59 isolates was higher than that in <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>910 (p\u00a0=\u00a00.02) and the <jats:italic>hla<\/jats:italic> expression in <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>59\u2010<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>mecV\u2010t437 was higher than that in <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>59\u2010<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>mec<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>a\u2010t437. Approximately, 46.4% (13\/28) of the infections caused by <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>59\u2010<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>mecV were invasive. This value is higher than that of <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>59\u2010<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>mecVa caused infections (14\/59, 23.7%) (p\u00a0=\u00a00.03). This study showed that neonatal <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content> infections in China readily become invasive, involve multiple organs, and are often accompanied by complications. The <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>mec V clone may be more pathogenic than the <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>mec<jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>a clone.<\/jats:p>","DOI":"10.1111\/apm.12304","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T14:45:38Z","timestamp":1407336338000},"page":"28-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical and molecular characteristics of community\u2010acquired methicillin\u2010resistant <i>Staphylococcus aureus<\/i> infections in Chinese neonates"],"prefix":"10.1111","volume":"123","author":[{"given":"Shipeng","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Children's Hospital Capital Medical University Beijing 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