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Primary specific morphology characteristics are known for some virus, like cytomegalovirus, parvovirus, and herpes simplex, however many viral infections show non\u2010specific changes. Placenta relevant cells as human first trimester trophoblasts <jats:styled-content style=\"fixed-case\">HTR<\/jats:styled-content>8\/<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>neo, primary human umbilical vein endothelial cells (<jats:styled-content style=\"fixed-case\">HUVEC<\/jats:styled-content>), and primary human embryonic fibroblasts were examined following infection with commonly occurring virus like adenovirus and enterovirus. Morphology in routine stained sections and virus\u2010specific immunostains were studied 4, 8, 24, 48, 72\u00a0h after infection. Nuclear enlargement was seen in the infected cells. 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