{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:11:49Z","timestamp":1761919909993},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Regions","award":["02\/2611"],"award-info":[{"award-number":["02\/2611"]}]},{"name":"The Danish Council for Independent Research","award":["09-069412"],"award-info":[{"award-number":["09-069412"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>The T\u2010allele in the single nucleotide polymorphism rs6897932 in the gene encoding the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20107 receptor \u03b1 (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>7<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content><\/jats:italic>) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection. Low\u2010grade inflammation (<jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>) and self\u2010reported, health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>) are often associated with chronic diseases and widely used in assessing and monitoring health status. The aim of the present study was to evaluate whether the T\u2010allele in rs6897932 is associated with reduced risk of <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content> (hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> 3\u201310\u00a0mg\/L), history of infectious mononucleosis (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> in healthy individuals. A total of 17, 293 healthy Danish individuals from the Danish Blood Donor Study were included in the analyses. We tested rs6897932 as a predictor of <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>, self\u2010reported <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> in univariable and multivariable models stratified by sex. No associations between rs6897932 and <jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>, self\u2010reported <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> were found in men or women. This suggests that rs6897932 is not associated with general inflammation, and the reported associations between the T\u2010allele in rs6897932 with several autoimmune diseases may be mediated through effects on a restricted part of the immune system.<\/jats:p>","DOI":"10.1111\/apm.12334","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T11:55:39Z","timestamp":1416916539000},"page":"169-174","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["No association between rs6897932 in the gene encoding interleukin\u20107 receptor \u03b1 and low\u2010grade inflammation or self\u2010reported health \u2013 results from the Danish Blood Donor Study"],"prefix":"10.1111","volume":"123","author":[{"given":"Hans J.","family":"Hartling","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Rigshospitalet Copenhagen University Hospital Copenhagen 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