{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:42:08Z","timestamp":1758123728031},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Hyperplastic polyps (HP) of the colon and rectum were previously considered benign. Newer studies have suggested that colorectal HP are different entities. The aim of this study was to reclassify lesions from a 5\u2010year period previously classified as colorectal HP into traditional hyperplastic polyp (THP), sessile serrated lesions (SSL), and other lesions. All patients were confirmed in the Danish National Pathology Database for the occurrence of metachronous polyps\/adenomas, colorectal cancer (CRC), and other gastrointestinal malignancies. Molecular pathology of the CRC were characterized and correlated with the index lesion. In total, 591 HP biopsy specimens were obtained from 480 patients. The lesions were reclassified as: 358 THP, 109 SSL, 35 TA, 81 unspecified non\u2010neoplastic lesions, four traditional serrated adenoma, and 4 SSL with cytological dysplasia. Seven patients developed CRC in the follow\u2010up period (1 patient had SSL, 4 had THP, and 2 had unspecified non\u2010neoplastic lesions). Ten patients developed other gastrointestinal malignancies. The patient with SSL as index lesions who developed CRC harbored V600E BRAF mutation in both index lesion and the carcinoma. Sixteen percent of patients with SSL subsequently developed a neoplastic lesion. Further studies are needed to clarify the cancer risk of SSL.<\/jats:p>","DOI":"10.1111\/apm.12355","type":"journal-article","created":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T07:37:00Z","timestamp":1424677020000},"page":"298-304","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hyperplastic polyps of the colon and rectum \u2013 reclassification, <scp>BRAF<\/scp> and <scp>KRAS<\/scp> status in index polyps and subsequent colorectal carcinoma"],"prefix":"10.1111","volume":"123","author":[{"given":"Huma Gul Rehana","family":"Janjua","sequence":"first","affiliation":[{"name":"Department of Pathology Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estrid","family":"H\u00f8gdall","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte","family":"Linnemann","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300843"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8608884"},{"key":"e_1_2_5_4_1","first-page":"131","volume-title":"World Health Organization, International Agency for Research on Cancer: World Health Organization Classification of Tumours of the Digestive System","author":"Bosman FT","year":"2010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000141404.56839.6a"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.037671"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.061960"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.4295"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.038"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/DRFQ0WFUF1G13CTK"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2011.05.003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.645499"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i27.3402"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.075507"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2010.11.007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319874"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1309\/VBAGV3BR96N2EQTR"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04356.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e4f256"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0143-4"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0407-7"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.126"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190901"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm496"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90835-Z"},{"key":"e_1_2_5_27_1","first-page":"45","article-title":"Pattern of hMLH1, hMSH2 and hMSH6 expression and clinical characteristics in a sample of Malaysian colorectal carcinoma cases","volume":"35","author":"Khoo JJ","year":"2013","journal-title":"Malays J Pathol"},{"key":"e_1_2_5_28_1","unstructured":"Danish Cancer Registry. 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