{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:47:42Z","timestamp":1781776062905,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Bureau of Wuxi","award":["CSE31N1418"],"award-info":[{"award-number":["CSE31N1418"]}]},{"name":"Health Bureau of Wuxi","award":["MS201417"],"award-info":[{"award-number":["MS201417"]}]},{"name":"Health Bureau of Wuxi","award":["FYKY201401"],"award-info":[{"award-number":["FYKY201401"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>We previously reported that micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 was frequently lost in cervical cancer and restoration of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 increased cellular radio\u2010sensitivity via inhibiting. Herein, we aim to investigate the effects of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 on cellular response to <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibition. The expression of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 and Rictor were measured by Taqman <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and real time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> in a panel of 15 cervical cancer tissues. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 was stably overexpressed in four cervical cancer cell lines and a series of <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> experiments were performed to investigate cellular sensitivity to Rapamycin. In primary cultured cervical cancer cells, the expression of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 was negatively correlated with the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level of Rictor, which predicted cellular sensitivity to Rapamycin (p\u00a0=\u00a00.002, R<jats:sup>2<\/jats:sup>\u00a0=\u00a00.6810). <jats:italic>In vitro<\/jats:italic>, overexpression of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 significantly reduced the level of Rictor and enhanced the growth\u2010inhibition, cell cycle arrest, and apoptosis induced by Rapamycin. <jats:italic>In vivo<\/jats:italic>, overexpression of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 further enhanced the suppressive effects of Rapamycin on tumor growth. In conclusion, we demonstrated that micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 could re\u2010sensitize cervical cancer to Rapamycin through targeting Rictor. Moreover, patients with loss of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 presented notable resistance to Rapamycin, indicating that micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010218 might be a valid marker for patients\u2010stratification in future clinical trials.<\/jats:p>","DOI":"10.1111\/apm.12387","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T06:43:02Z","timestamp":1429857782000},"page":"562-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Retracted:<\/i> Micro<scp>RNA<\/scp>\u2010218 increases cellular sensitivity to <scp>R<\/scp>apamycin via targeting <scp>R<\/scp>ictor in cervical cancer"],"prefix":"10.1111","volume":"123","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University 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