{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:53:25Z","timestamp":1782734005633,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Recently, very few studies have shown value of immunohistochemical (<jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>) expression of <jats:styled-content style=\"fixed-case\">INI<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">SMARCB<\/jats:styled-content>1 in diagnosis of synovial sarcomas (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s). This study was aimed at testing reproducibility and utility of this finding. Sixty\u2010eight <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s and 147 other tumours, in the form of various biopsies, were tested for <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content> expression of <jats:styled-content style=\"fixed-case\">INI<\/jats:styled-content>1. Twenty\u2010six <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s were further confirmed with positive <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>18 rearrangement. Forty monophasic spindle cell type (58.8%), 13 biphasic (19.1%), 12 poorly differentiated (17.6%) and three calcifying <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s (4.4%) were positive for epithelial membrane antigen (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>) (46\/62) (74.1%), pan cytokeratin (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>3) (31\/47) (65.9%), cytokeratin (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>7) (20\/31) (64.5%), <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2 (62\/66) (93.9%), <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>2 (61\/63) (96.8%), transducin\u2010like enhancer of split 1 (<jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>1) (29\/31) (93.5%) and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19 (14\/24) (58.3%). <jats:styled-content style=\"fixed-case\">INI<\/jats:styled-content>1 expression was \u2018weak to absent\u2019 in 60\/68 (88.2%) <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s; in 1\/3 atypical ossifying fibromyxoid tumours (<jats:styled-content style=\"fixed-case\">AOFMT<\/jats:styled-content>s) and in 3\/10 (30%) malignant peripheral nerve sheath tumours (<jats:styled-content style=\"fixed-case\">MPNST<\/jats:styled-content>s) of various types. <jats:styled-content style=\"fixed-case\">INI<\/jats:styled-content>1 was completely absent in 10\/10 (100%) epithelioid sarcomas (<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>s), 4\/4 (100%) malignant rhabdoid tumours, single paediatric undifferentiated sarcoma, 5\/19 (26.3%) myoepithelial carcinomas and in 2\/4 (50%) epithelioid\u2010subtype of <jats:styled-content style=\"fixed-case\">MPNST<\/jats:styled-content>s. Remaining 100 tumours, including 12 <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>wing sarcomas, 15 carcinomas, eight solitary fibrous tumours (<jats:styled-content style=\"fixed-case\">SFT<\/jats:styled-content>), seven extraskeletal myxoid chondrosarcomas, three fibrosarcomas and other tumours retained <jats:styled-content style=\"fixed-case\">INI<\/jats:styled-content>1 expression. A unique \u2018weak to absent\u2019 <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content> expression of <jats:styled-content style=\"fixed-case\">INI<\/jats:styled-content>1 is highly sensitive (88.2%) and specific (97.3%) for a <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>, irrespective of its subtypes and types of biopsies. This can be considered useful in diagnosing <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s, especially in settings lacking molecular and\/or cytogenetic analysis. A similar <jats:styled-content style=\"fixed-case\">INI<\/jats:styled-content>1 expression is shared by certain <jats:styled-content style=\"fixed-case\">AOFMT<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">MPNST<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/apm.12395","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T07:23:07Z","timestamp":1429860187000},"page":"618-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Utility of characteristic \u2018<scp>W<\/scp>eak to <scp>A<\/scp>bsent\u2019 <scp>INI<\/scp>1\/<scp>SMARCB<\/scp>1\/<scp>BAF<\/scp>47 expression in diagnosis of synovial\u00a0sarcomas"],"prefix":"10.1111","volume":"123","author":[{"given":"Bharat","family":"Rekhi","sequence":"first","affiliation":[{"name":"Department of Pathology Tata Memorial Centre Parel Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Vogel","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Tuebingen Eberhard\u2010Karls\u2010University Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"213","volume-title":"Tumours of Soft Tissue and Bone. 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