{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:14:09Z","timestamp":1759742049692},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Yolk sac tumor (<jats:styled-content style=\"fixed-case\">YST<\/jats:styled-content>), also known as endodermal sinus tumor, is a highly malignant germ cell tumor that is extremely rare in the sinonasal region, especially in adults. To the best of our knowledge, only five such cases have been reported till date (four men, one woman). We present a case of sinonasal <jats:styled-content style=\"fixed-case\">YST<\/jats:styled-content> admixed with transitional cell carcinoma in a 58\u2010year\u2010old female. Magnetic resonance imaging revealed a mass in the right ethmoid fissure infiltrating\u00a0into the posterior and anterior ethmoid sinuses and nasopharynx. Positron emission tomography examination showed a maximum standardized uptake value of 6.8. Histological examination of the biopsy specimen revealed two distinct features, <jats:styled-content style=\"fixed-case\">YST<\/jats:styled-content> and transitional cell carcinoma, with evidence of mutual transition that indicated the composite nature of the tumor. Immunohistochemical analysis revealed positive immunoreactivity for Sal\u2010like protein 4, \u03b1\u2010fetoprotein and glypican3, and negative immunoreactivity for placental alkaline phosphatase, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117 in the <jats:styled-content style=\"fixed-case\">YST<\/jats:styled-content> component. P40 and P63 were detected only in transitional cell carcinoma component. The tumor was subsequently excised and four cycles of adjuvant chemotherapy at intervals of 3\u00a0weeks were administered. At 8\u00a0months after surgery, there was no evidence of tumor recurrence or metastasis. We have also presented a literature review on <jats:styled-content style=\"fixed-case\">YST<\/jats:styled-content> in sinusoids.<\/jats:p>","DOI":"10.1111\/apm.12409","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T17:21:51Z","timestamp":1434734511000},"page":"810-814","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sinonasal yolk sac (Endodermal sinus) tumor in an adult female \u2013 A case report and review of the literature"],"prefix":"10.1111","volume":"123","author":[{"given":"Xianglin","family":"Mei","sequence":"first","affiliation":[{"name":"Department of Pathology The second hospital of Jilin university Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathology The second hospital of Jilin university Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Laboratory Tohoku University School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology The second hospital of Jilin university Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80004-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-009-0880-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1670"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-012-3173-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21752"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2007.09.001"},{"key":"e_1_2_7_8_1","first-page":"198","article-title":"Transitional (cylindric) cell carcinoma with endodermal sinus tumor\u2010like features of the nasopharynx and paranasal sinuses. 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