{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:25:06Z","timestamp":1792445106342,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:00:00Z","timestamp":1436313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) is a common malignant hematological disease displaying considerable heterogeneity. Historical data indicate a prognostic significance of plasmablastic morphology, proliferation, and adverse cytogenetics, but there is little knowledge on the degree of interdependency of these parameters. The aim of this study was to study the degree of overlap between these variables. In a consecutive population\u2010based cohort of 194 untreated <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> patients, morphology, and proliferation index, using immunohistochemical double staining for <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138, was analyzed. In addition, cytogenetic changes were studied by karyotyping and fluorescence <jats:italic>in\u00a0situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>). Plasmablastic morphology correlated with unfavorable clinical features, high proliferation index, high percentage of plasma cell infiltration in the bone marrow, abnormal karyotype, and del(13q) detected by karyotyping, which indicates that plasmablastic morphology reflects advanced and highly proliferative disease. However, plasmablastic morphology did not correlate with established adverse prognostic cytogenetics identified by <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>, for example, t(4;14), t(14;16) and del(17p).<\/jats:p>","DOI":"10.1111\/apm.12411","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T06:30:07Z","timestamp":1436337007000},"page":"652-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinicopathological features of plasmablastic multiple myeloma: a population\u2010based cohort"],"prefix":"10.1111","volume":"123","author":[{"given":"Hanne E. 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