{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:59:31Z","timestamp":1723165171202},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\u2010rich interactive domain 1A (<jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A) is a tumor suppressor gene involved in chromatin remodeling which encodes <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A (<jats:styled-content style=\"fixed-case\">BAF<\/jats:styled-content>250a) protein. Recent studies have shown the loss of <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A expression in several types of tumors. This retrospective study was designed to evaluate the differences in tissue expressions of <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A in a spectrum of cervical neoplasms. Cervical intraepithelial neoplasms, invasive squamous or adenosquamous carcinomas were identified in 100 patients recently diagnosed as cervical neoplasms based on pathology databases. In this series, there were 29 low\u2010 and 29 high\u2010grade cervical intraepithelial neoplasms, 27 squamous cell carcinomas, and 15 adenosquamous carcinomas. Mean age of the patients was 47.8\u00a0\u00b1\u00a013\u00a0years (20\u201380\u00a0years). It was determined that the expression of <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A was statistically significantly down\u2010regulated in adenosquamous carcinomas when compared with non\u2010invasive or invasive squamous cell carcinomas (p\u00a0=\u00a00.015). Lower levels of the <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A expression were detected in cases with adenosquamous carcinomas (60%), low\u2010 or high\u2010grade squamous intraepithelial lesion (<jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content>) (31%), and squamous cell carcinomas (18.5%). Our findings have demonstrated the presence of a correlation between <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A expression and adenomatous differentiation of uterine squamous cell carcinomas. Therefore, <jats:styled-content style=\"fixed-case\">ARID<\/jats:styled-content>1A gene may suggestively have a role in the pathogenesis of cervical adenosquamous carcinomas.<\/jats:p>","DOI":"10.1111\/apm.12435","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T08:21:36Z","timestamp":1440490896000},"page":"847-850","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences in the <scp>ARID<\/scp>\u20101 alpha expressions in squamous and adenosquamous carcinomas of uterine cervix"],"prefix":"10.1111","volume":"123","author":[{"given":"Dudu","family":"Solakoglu Kahraman","sequence":"first","affiliation":[{"name":"Pathology Laboratory Tepecik Education and Research Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulden","family":"Diniz","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Tepecik Education and Research 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