{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:00:41Z","timestamp":1789365641798,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u00d6sterg\u00f6tland County Council"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>In recent years, coagulase\u2010negative staphylococci such as <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>taphylococcus epidermidis<\/jats:italic> have gained importance as nosocomial pathogens, especially in immunocompromised patients and prosthetic joint infections (<jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content>s). These infections are often long lasting and difficult to treat due to the production of bacterial biofilm and the transformation of the bacteria into a stationary growth phase. Rifampicin is able to penetrate the biofilm, but to reduce the risk of development of rifampicin resistance it should be used in combination with an additional antibiotic. In this study we used Etest to investigate the antimicrobial susceptibility of 134 clinical isolates of <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0epidermidis<\/jats:italic> obtained from <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content>s to six oral antibiotics: doxycycline, rifampicin, linezolid, fusidic acid, clindamycin, and ciprofloxacin. We also performed synergy testing on doxycycline in combination with each of the remaining antibiotics. Ninety\u2010three (69%) of the 134 isolates were susceptible to doxycycline, 94\/134 (70%) to rifampicin, 56\/134 (42%) to clindamycin, 25\/134 (19%) to ciprofloxacin, 81\/134 (60%) to fusidic acid, and 100% to linezolid. Thirty\u2010two (80%) of the 40 isolates not fully susceptible to rifampicin were susceptible to doxycycline. Doxycycline in combination with each of the other investigated antibiotics exerted an additive effect on nearly half of the isolates, with the exception of clindamycin, which displayed an even higher percentage of additive effect (69%). To conclude, as the majority of the <jats:italic>S.\u00a0epidermidis<\/jats:italic> isolates were susceptible to doxycycline, this antimicrobial agent may provide a potential alternative for combination therapy together with rifampicin.<\/jats:p>","DOI":"10.1111\/apm.12465","type":"journal-article","created":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T19:13:26Z","timestamp":1447010006000},"page":"1055-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antibiotic susceptibility among <i><scp>S<\/scp>taphylococcus epidermidis<\/i> isolated from prosthetic joint infections, with focus on doxycycline"],"prefix":"10.1111","volume":"123","author":[{"given":"Tarza","family":"Hamad","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Hellmark","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Nilsdotter\u2010Augustinsson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"S\u00f6derquist","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"StefansdottirA.Thesis; 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