{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T21:55:16Z","timestamp":1781387716614,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\">HOBX<\/jats:styled-content>13 is a transcription factor expressed in the normal prostatic glands and overexpressed in prostate cancer. Recent studies suggested that <jats:styled-content style=\"fixed-case\">HOXB<\/jats:styled-content>13 represents a prostate\u2010specific marker in the differential diagnosis between prostatic and urothelial carcinoma. The aim of this study was to analyze and compare the diagnostic value of <jats:styled-content style=\"fixed-case\">HOXB<\/jats:styled-content>13 and prostate\u2010specific antigen (<jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>) immunoexpression for the detection of prostatic origin in metastatic tumours. <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HOXB<\/jats:styled-content>13 immunohistochemical expression was assessed in 50 metastatic tumors, including 15 metastases from prostatic adenocarcinoma, 11 from lung adenocarcinoma, 12 from urinary bladder urothelial carcinoma, 11 from colorectal carcinoma, and in 1 from hepatocellular carcinoma. Strong staining for <jats:styled-content style=\"fixed-case\">HOXB<\/jats:styled-content>13 was observed in &gt;75% of neoplastic cells in 15\/15 (100%) metastases from prostate cancer. Weak staining in &lt;25% of cells was found in 2\/12 (17%) metastases from urothelial carcinoma. <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content> immunostaining was detected only in 8 (53%) cases of prostatic origin. The sensitivity and specificity for metastatic prostate cancer were 100% and 94% for <jats:styled-content style=\"fixed-case\">HOXB<\/jats:styled-content>13 and 53% and 100% for <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>. Due to its high sensitivity and specificity, <jats:styled-content style=\"fixed-case\">HOXB<\/jats:styled-content>13 may be included in the pool of prostate\u2010specific markers in metastases showing absent or weak staining for <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content> before excluding prostatic derivation.<\/jats:p>","DOI":"10.1111\/apm.12483","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T04:15:03Z","timestamp":1448079303000},"page":"188-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>HOXB<\/scp>13 as an immunohistochemical marker of prostatic origin in metastatic tumors"],"prefix":"10.1111","volume":"124","author":[{"given":"Valeria","family":"Barresi","sequence":"first","affiliation":[{"name":"Department of Human Pathology \u201cG. 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