{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:19:26Z","timestamp":1757456366551},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Human gastric diseases have shown significant changes in the activity and expression of superoxide dismutase (<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>) isoforms. The aim of this study was to detect Mn\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> activity and expression in the tissue of gastric mucosa, primarily in chronic gastritis (immunohistochemical <jats:italic>Helicobacter pylori<\/jats:italic>\u2010negative gastritis, without other pathohistological changes) and to evaluate their possible connection with pathohistological diagnosis. We examined 51 consecutive outpatients undergoing endoscopy for upper gastrointestinal symptoms. Patients were classified based on their histopathological examinations and divided into three groups: 51 patients (archive samples between 2004\u20132009) with chronic immunohistochemical <jats:italic>Helicobacter pylori<\/jats:italic>\u2010negative gastritis (mononuclear cells infiltration were graded as absent, moderate, severe) divided into three groups. Severity of gastritis was graded according to the updated Sydney system. Gastric tissue samples were used to determine the expression of Mn\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> with anti\u2010Mn\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> Ab immunohistochemically. The Mn\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> expression was more frequently present in specimens with severe and moderate inflammation of gastric mucosa than in those with normal mucosa. In patients with normal histological finding, positive immunoreactivity of Mn\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> was not found. Our results determine the changes in Mn\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> expression occurring in the normal gastric mucosa that had undergone changes in the intensity of chronic inflammatory infiltrates in the lamina propria.<\/jats:p>","DOI":"10.1111\/apm.12496","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T16:29:51Z","timestamp":1452788991000},"page":"252-256","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Superoxide dismutases in chronic gastritis"],"prefix":"10.1111","volume":"124","author":[{"given":"Dra\u017een","family":"\u0160vagelj","sequence":"first","affiliation":[{"name":"Department of Pathology and Cytology General Hospital Vinkovci Vinkovci Croatia"},{"name":"Department of Pathology Faculty of Medicine University of Osijek Osijek Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velimir","family":"Terzi\u0107","sequence":"additional","affiliation":[{"name":"Department of Urology General Hospital Vinkovci Vinkovci Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasna","family":"Dovhanj","sequence":"additional","affiliation":[{"name":"Department of Clinical and Laboratory Diagnostics Faculty of Medicine University of Osijek Osijek Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"\u0160vagelj","sequence":"additional","affiliation":[{"name":"Department of Surgery General Hospital Vinkovci Vinkovci Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta","family":"Cvrkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology General Hospital Vinkovci Vinkovci Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"\u0160vagelj","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology General Hospital Vinkovci Vinkovci Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.12.009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.10.024"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.4.502"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1407"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5258"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90245-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161-069X.1000150"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00868-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100002125001135"},{"issue":"2","key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/milmed\/167.suppl_1.71","article-title":"Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene","volume":"167","author":"Epperly MW","year":"2002","journal-title":"Mil Med"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12192"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.01331.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109801200"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/15230860152409095"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.12.1204"},{"key":"e_1_2_5_17_1","first-page":"3183","article-title":"Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer","volume":"6","author":"Miranda A","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708786848587"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/35030140"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13547500600899134"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365297"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i28.4305"},{"key":"e_1_2_5_24_1","first-page":"4309","article-title":"Superoxide\u2010dismutase activity of the gastric mucosa in patients with Helicobacter pylori infection","volume":"23","author":"Farkas R","year":"2003","journal-title":"Anticancer Res"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2002.00107.x"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:07:13Z","timestamp":1696496833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/apm.12496"],"URL":"https:\/\/doi.org\/10.1111\/apm.12496","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,14]]},"assertion":[{"value":"2015-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}