{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:17:08Z","timestamp":1758961028013},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p><jats:italic>Enterobacter aerogenes<\/jats:italic> has recently emerged as an important hospital pathogen. In this study, we showed the emergence of <jats:italic>E. aerogenes<\/jats:italic> isolates carrying the <jats:italic>bla<\/jats:italic><jats:sub><jats:italic><jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content><\/jats:italic><\/jats:sub> gene in patients colonized by carbapenem\u2010resistant <jats:italic>Klebsiella pneumoniae<\/jats:italic> strains. Two multiresistant <jats:italic>E. aerogenes<\/jats:italic> isolates were recovered from bronchial aspirates of two patients hospitalized in the Intensive Care Unit at the \u201cSanta Maria della Scaletta\u201d Hospital, Imola. The antimicrobial susceptibility test showed the high resistance to carbapenems and double\u2010disk synergy test confirmed the phenotype of <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content> and AmpC production. Other investigation revealed that <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>bla<\/jats:italic><jats:sub><jats:italic>KPC<\/jats:italic><\/jats:sub><\/jats:styled-content> genes were carried on the conjugative <jats:styled-content style=\"fixed-case\">pKpQIL<\/jats:styled-content> plasmid. This is a relevant report in Italy that describes a nosocomial infection due to the production of <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content> beta\u2010lactamases by an <jats:italic>E. aerogenes<\/jats:italic> isolate in patients previously colonized by <jats:italic>K. pneumoniae<\/jats:italic> carbapenem\u2010resistant. In conclusion, it's necessary a continuous monitoring of multidrug\u2010resistant strains for the detection of any <jats:styled-content style=\"fixed-case\">KPC<\/jats:styled-content>\u2010producing bacteria that could expand the circulation of carbapenem\u2010resistant pathogens.<\/jats:p>","DOI":"10.1111\/apm.12528","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T02:40:39Z","timestamp":1458700839000},"page":"516-521","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Isolation of <i>Enterobacter aerogenes<\/i> carrying <i>bla<\/i><sub><i>TEM\u20101<\/i><\/sub> and <i>bla<\/i><sub><i>KPC\u2010<\/i>3<\/sub> genes recovered from a hospital Intensive Care Unit"],"prefix":"10.1111","volume":"124","author":[{"given":"Giovanna","family":"Pulcrano","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology Federico II University Medical School Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Pignanelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Services S. 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