{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:25:54Z","timestamp":1762323954721},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Primary Ewing sarcoma or primitive neuroectodermal tumor (<jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content>) of the adrenal gland is extremely rare. We report a case of Ewing sarcoma or <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> of the adrenal in a 48\u2010year\u2010old Chinese woman. The patient was hospitalized with left upper quadrant abdominal pain and swelling that had been present for 1 year. Computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) images revealed a circumscribed mass in the left adrenal region measuring 12 cm in its greatest dimension, and the mass was surgically resected. Macroscopically, the mass (13 \u00d7 10 \u00d7 8 cm<jats:sup>3<\/jats:sup>) in the left adrenal gland was encapsulated, soft, appearing grayish white and yellow, and with foci of cystic degeneration, necrosis, and hemorrhage on cross\u2010sectional. Non\u2010tumorous adrenal tissue was compressed, but identifiable at the periphery of the specimen. Histologically, compact short spindle and oval tumor cells were arranged in sheets. Tumor cells tested positive for vimentin, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>99, Bcl\u20102, <jats:styled-content style=\"fixed-case\">NKX<\/jats:styled-content>2.2, <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117, and weakly positive for <jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>\u20101 on immunohistochemical analysis and showed rearrangement of the <jats:italic><jats:styled-content style=\"fixed-case\">EWSR<\/jats:styled-content>1<\/jats:italic> on fluorescence <jats:italic>in situ<\/jats:italic> hybridization analysis. Post\u2010adrenalectomy, after being recurrence free for 4.5 years, the patient relapsed and a localized recurrence was detected on a follow\u2010up <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan.<\/jats:p>","DOI":"10.1111\/apm.12544","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T16:06:38Z","timestamp":1463846798000},"page":"624-629","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Primary Ewing sarcoma\/primitive neuroectodermal tumor in the adrenal gland"],"prefix":"10.1111","volume":"124","author":[{"given":"Lian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology The Second Hospital of Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology The Second Hospital of Jilin University 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