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Seventy\u2010five children (37 male, mean age 8.4 \u00b1 4.8 years), who randomly underwent small bowel biopsy, were studied. The <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> was diagnosed in 14 children, including five persons with concomitant <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (all positive for anti\u2010tissue transglutaminase IgA antibodies and with small bowel atrophy). Normal small bowel mucosa was found in eight patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and in 53 patients with <jats:styled-content style=\"fixed-case\">FGD<\/jats:styled-content>. The sera of all patients were tested for total and specific IgE antibodies to food allergen panels. Staining for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c+, langerin (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>207+) <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+, and <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3+ Treg cells was performed on paraffin\u2010embedded sections of bioptates using immunohistochemistry. The density of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c+ <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+, and <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3+ Treg cells was higher in the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients compared to the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FGD<\/jats:styled-content> patients (p = 0.02; p = 0.001). In <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, significantly higher density of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c+ <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s was detected in patients positive for specific IgE to food allergen panels (p = 0.02). The <jats:styled-content style=\"fixed-case\">FGD<\/jats:styled-content> patients with elevated total IgE had increased density of langerin (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>207)+ <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s compared to the patients with normal total IgE levels (p = 0.01). The increased density of <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3+ Treg cells, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+, cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c+ <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s was associated with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> but not with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. The elevated level of total IgE or specific IgE to food allergens was associated with more pronounced expression of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, indicating a possible link between the presence of these cells in small bowel mucosa with elevated level of serum IgE.<\/jats:p>","DOI":"10.1111\/apm.12552","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T22:23:24Z","timestamp":1463869404000},"page":"689-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of langerin (CD207)+ dendritic cells and FOXP3+ Treg cells in the small bowel mucosa of children with celiac disease and atopic dermatitis in comparison to children with functional gastrointestinal disorders"],"prefix":"10.1111","volume":"124","author":[{"given":"Tamara","family":"Vorobjova","sequence":"first","affiliation":[{"name":"Department of Immunology Institute of 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