{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:17:43Z","timestamp":1767982663812,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571591"],"award-info":[{"award-number":["81571591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>It is necessary and useful to explore prevalence of various systemic autoimmune rheumatic diseases (<jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s) in patients with suspicion of having <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s and to characterize antinuclear antibodies (<jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>) profile for identifying different populations (<jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s and non\u2010<jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s). A total of 5024 consecutive patients with available medical records were investigated, whose sera had been tested for <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> profile, including <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>, anti\u2010ds<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> and anti\u2010extractable nuclear antigen (<jats:styled-content style=\"fixed-case\">ENA<\/jats:styled-content>) antibodies, between 31 January 2012 and 26 March 2014. Only 594 (11.8%) patients were diagnosed with <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s of those suspected with <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s. The prevalence of systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) was highest (3.2%), followed by rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) (2.5%), primary Sj\u00f6gren's syndrome (<jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>) (1.7%), ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) (1.5%), etc. Of females, <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> also showed the highest prevalence (6%), while of males, <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> showed the highest prevalence (1.9%). The prevalence of most <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s was closely associated with age, except mixed connective tissue disease (<jats:styled-content style=\"fixed-case\">MCTD<\/jats:styled-content>), and the variation characteristics among different age groups were different among various <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s. The prevalence of <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> was significantly increased in most <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content> patients [especially in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) and <jats:styled-content style=\"fixed-case\">MCTD<\/jats:styled-content>]. For anti\u2010<jats:styled-content style=\"fixed-case\">ENA<\/jats:styled-content> antibodies, in contrast to some autoantibodies associated with multiple <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s (e.g. anti\u2010<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SSB<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> nRNP<\/jats:styled-content>), others were relatively specific for certain diseases, such as anti\u2010ds<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, Sm, histone, nucleosome and Rib\u2010P for <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, anti\u2010<jats:styled-content style=\"fixed-case\">SCL<\/jats:styled-content>\u201070 for <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and anti\u2010Jo\u20101 for polymyositis\/dermatomyositis (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>). Of note, <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> profile appeared to be of little significance for <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ANCA<\/jats:styled-content>\u2010associated vasculitis (<jats:styled-content style=\"fixed-case\">AAV<\/jats:styled-content>), polymyalgia rheumatic (<jats:styled-content style=\"fixed-case\">PMR<\/jats:styled-content>), adult\u2010onset Still's disease (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) and Behcet's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>). The younger were more likely to have the presence of anti\u2010ds<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, Sm, histone or Rib\u2010P for <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, and anti\u2010<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">MCTD<\/jats:styled-content>. No significant differences for frequencies of <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> and anti\u2010<jats:styled-content style=\"fixed-case\">ENA<\/jats:styled-content> autoantibodies were found between sexes in most <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s, with the exception of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>. The present study suggests that, of patients with <jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>s\u2010like clinical manifestations, the proportion of those with true <jats:styled-content style=\"fixed-case\">SARDS<\/jats:styled-content> is small, for most of whom tests for autoantibodies are necessary and useful to help make a prompt and precise diagnosis.<\/jats:p>","DOI":"10.1111\/apm.12564","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T05:44:49Z","timestamp":1466660689000},"page":"805-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence of systemic autoimmune rheumatic diseases and clinical significance of <scp>ANA<\/scp> profile: data from a tertiary hospital in <scp>S<\/scp>hanghai, <scp>C<\/scp>hina"],"prefix":"10.1111","volume":"124","author":[{"given":"Zaixing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Laboratory Diagnostics Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingpeng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Taizhou First People's Hospital Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Taizhou First People's Hospital Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of General Surgery Taizhou First People's Hospital Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61499-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203863"},{"key":"e_1_2_6_4_1","first-page":"336","article-title":"Frequency of rheumatic diseases in Portugal: a systematic review","volume":"36","author":"Monjardino T","year":"2011","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.86"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2669"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"e_1_2_6_11_1","first-page":"1332","article-title":"Early undifferentiated connective tissue disease. 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