{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:36:00Z","timestamp":1773884160584,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400981"],"award-info":[{"award-number":["81400981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>This study was to investigate the differences of lymphocyte in the cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) of patients with syphilis meningitis (<jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>) and tuberculous meningitis (<jats:styled-content style=\"fixed-case\">TBM<\/jats:styled-content>) for new diagnostic insights. Totally, 79 cases of <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> and 45 cases of <jats:styled-content style=\"fixed-case\">TBM<\/jats:styled-content> were enrolled. In the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RO<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 positive lymphocytes were detected by immunohistochemistry. The proportion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 T cells in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> lymphocytes in patients with <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> was significantly higher than that in patients with <jats:styled-content style=\"fixed-case\">TBM<\/jats:styled-content> (p &lt; 0.05). After medical therapy, there was a significantly decline trend of the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 T\u2010cell proportion in both groups (p &lt; 0.05). The proportion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RO<\/jats:styled-content> T cells in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> lymphocytes of patients with <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> was less than that of patients with <jats:styled-content style=\"fixed-case\">TBM<\/jats:styled-content> (p &lt; 0.05). After medical therapy, the positive ratio of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RO<\/jats:styled-content> T cells was increased in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> of both group patients (p &lt; 0.05). The proportion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20B cells in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> lymphocytes was not obviously different between the two groups during every stage. In conclusion, there are strong differences of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RO<\/jats:styled-content> T\u2010cell ratio, but not the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 B cells in the meningitis. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45<jats:styled-content style=\"fixed-case\">RO<\/jats:styled-content> T cells in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> are a useful complement in differentially diagnosing <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TBM<\/jats:styled-content>; it contributes to further understand the pathogenesis and prognosis of <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TBM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.12572","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T12:48:54Z","timestamp":1469710134000},"page":"764-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparative study of CD4 and CD45RO T cells and CD20 B cells in cerebrospinal fluid of syphilitic meningitis and tuberculous meningitis patients"],"prefix":"10.1111","volume":"124","author":[{"given":"Nian","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurology Nanjing Medical University, Affiliated Nanjing Brain Hospital Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao\u2010quan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Nanjing Medical University, Affiliated 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