{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:41:19Z","timestamp":1774802479531,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["21\u20102005\u20100110"],"award-info":[{"award-number":["21\u20102005\u20100110"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Postherpetic neuralgia (<jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>), the most frequent complication of varicella\u2010zoster virus reactivation, is characterized by pain that persists for more than 3 months, often for years after healing of zoster rash. A few studies revealing the association of human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) with <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> have been reported, but only in the Japanese. The aim of this study was to investigate the primary <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> locus associated with <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> susceptibility in Koreans. We compared <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A, \u2010B, \u2010C, and <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 genotypes of 66 <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> patients with those of 54 herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) patients without developing <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> and 235 healthy controls. Frequencies of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*13<\/jats:italic>,<jats:italic> B*44<\/jats:italic>,<jats:italic> B*15<\/jats:italic> (B75), <jats:italic><jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*10:01<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*12:02<\/jats:italic> were increased, and those of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*01<\/jats:italic>,<jats:italic> C*12<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*01:01<\/jats:italic> were decreased in <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> patients compared to those in controls (each, p &lt; 0.05). Among these alleles, only the frequency of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*44<\/jats:italic> was significantly increased in <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> patients compared to that in <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> patients and the change was due to <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*44:03<\/jats:italic> (<jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> vs controls, p = 0.043; <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> vs <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>, p = 0.012). The results suggest that <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*44:03<\/jats:italic> or other closely linked gene of the major histocompatibility complex is associated with susceptibility to the development of <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>, but not with the onset of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.12575","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T04:43:10Z","timestamp":1469508190000},"page":"865-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of human leukocyte antigen with postherpetic neuralgia in Koreans"],"prefix":"10.1111","volume":"124","author":[{"given":"Hye Yoon","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Ah","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Hun","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul 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