{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:32:10Z","timestamp":1792740730318,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["192477"],"award-info":[{"award-number":["192477"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    Meningococci (\n                    <jats:italic>Neisseria meningiditis)<\/jats:italic>\n                    of serogroups A and W have caused large epidemics of meningitis in sub\u2010Saharan Africa for decades, and affordable and multivalent vaccines, effective in all age groups, are needed. A bivalent serogroup A and W (A + W) meningococcal vaccine candidate consisting of deoxycholate\u2010extracted outer membrane vesicles (\n                    <jats:styled-content style=\"fixed-case\">OMV<\/jats:styled-content>\n                    ) from representative African disease isolates was previously found to be highly immunogenic in outbred mice when formulated with the adjuvant aluminium hydroxide (\n                    <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">OMV<\/jats:styled-content>\n                    has been shown to have inherent adjuvant properties. In order to study the importance of\n                    <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>\n                    and genetical differences between mice strains on immune responses, we compared the immunogenicity of the A + W\n                    <jats:styled-content style=\"fixed-case\">OMV<\/jats:styled-content>\n                    vaccine when formulated with or without\n                    <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>\n                    in inbred C57\n                    <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\n                    \/6J and\n                    <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">cJ<\/jats:styled-content>\n                    mice (Th1 and Th2 dominant strains, respectively). The immunogenicity of the vaccine was found to be comparable in the two mice strains despite their different immune profiles. Adsorption to\n                    <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>\n                    increased anti\u2010\n                    <jats:styled-content style=\"fixed-case\">OMV<\/jats:styled-content>\n                    IgG levels and serum bactericidal activity (\n                    <jats:styled-content style=\"fixed-case\">SBA<\/jats:styled-content>\n                    ). The immune responses were increased by each dose for the adsorbed vaccine, but the third dose did not significantly improve the immunogenicity further. Thus, a vaccine formulation with the A and W\n                    <jats:styled-content style=\"fixed-case\">OMV<\/jats:styled-content>\n                    will likely benefit from including\n                    <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>\n                    as adjuvant.\n                  <\/jats:p>","DOI":"10.1111\/apm.12589","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T23:38:46Z","timestamp":1474414726000},"page":"996-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immune responses of a meningococcal A + W outer membrane vesicle (OMV) vaccine with and without aluminium hydroxide adjuvant in two different mouse strains"],"prefix":"10.1111","volume":"124","author":[{"given":"Gro","family":"Tunheim","sequence":"first","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Arnemo","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"},{"name":"Department of Pharmaceutical Biosciences School of Pharmacy University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth M.","family":"N\u00e6ss","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnstein","family":"Norheim","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Garcia","sequence":"additional","affiliation":[{"name":"Finlay Institute Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Finlay Institute Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleida","family":"Mandiarote","sequence":"additional","affiliation":[{"name":"Finlay Institute Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Finlay Institute Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Sinnadurai","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5se\u2010Karine","family":"Fjeldheim","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Bolstad","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar","family":"Rosenqvist","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health (NIPH) Domain for Infection Control and Environmental Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Cerebrospinal meningitis in Africa","volume":"28","author":"Lapeyssonnie L","year":"1963","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90106-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.861-871.2006"},{"key":"e_1_2_6_5_1","unstructured":"NorheimG RosenqvistE HoibyEA CaugantDA.Comparison of serogrop A Neisseria meningitidis strains of sequence type 2859 emerging in Burkina Faso in meningitis seasons 2003 and 2004 with predominating ST\u20107 strains [abstract] 16th International Pathogenic Neisseria Conference 7\u201012 September. 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