{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:45:47Z","timestamp":1791477947794,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP 2008\/06493\u20100"],"award-info":[{"award-number":["FAPESP 2008\/06493\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["471149\/2011\u20100"],"award-info":[{"award-number":["471149\/2011\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p><jats:italic>Aspergillus fumigatus<\/jats:italic> is the main causative agent of invasive aspergillosis, a disease that affects immunocompromised patients and has a high mortality rate. We previously observed that the transcription of a <jats:italic>cipC<\/jats:italic>\u2010like gene was increased when <jats:italic>A. fumigatus<\/jats:italic> encountered an increased <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> concentration, as occurs during the infection process. CipC is a protein of unknown function that might be associated with fungal pathogenicity. In this study, the <jats:italic>cipC<\/jats:italic> gene was disrupted in <jats:italic>A. fumigatus<\/jats:italic> to evaluate its importance for fungal pathogenicity. The gene was replaced, and the germination, growth phenotype, stress responses, and virulence of the resultant mutant were assessed. Although <jats:italic>cipC<\/jats:italic> was not essential, its deletion attenuated <jats:italic>A. fumigatus<\/jats:italic> virulence in a low\u2010dose murine infection model, suggesting the involvement of the <jats:italic>cipC<\/jats:italic> gene in the virulence of this fungus. This study is the first to disrupt the <jats:italic>cipC<\/jats:italic> gene in <jats:italic>A. fumigatus<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/apm.12648","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T04:45:39Z","timestamp":1485319539000},"page":"141-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>cipC<\/i> is important for <i>Aspergillus fumigatus<\/i> virulence"],"prefix":"10.1111","volume":"125","author":[{"given":"Heliara Maria Spina","family":"Canela","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Akira","family":"Takami","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo 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