{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:23:40Z","timestamp":1768778620905,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Altered expression of carbonic anhydrase (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> is associated with human carcinogenesis. We analysed <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> protein expression in 89 patients with pseudomyxoma peritonei (<jats:styled-content style=\"fixed-case\">PMP<\/jats:styled-content>) and correlated its association against survival. We determined the expression of <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> by immunohistochemistry and then scored the staining results. The correlations of <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> expression with Peritoneal Cancer Index (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>) and tumour grade were examined. The effect of <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> and tumour grade on survival was investigated. Positive <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> expression was found in 58 patients (65%) and absent in 31 patients (35%). High\u2010grade (<jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content>) morphology was associated with a loss of <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> expression (p\u00a0=\u00a00.048). The mean <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> immunostaining intensity score was 1.00\u00a0\u00b1\u00a01.1 (median 1, range 0\u20133) for <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content> morphology and 1.54\u00a0\u00b1\u00a01.1 (median 2, range 0\u20133) for low\u2010grade (<jats:styled-content style=\"fixed-case\">LG<\/jats:styled-content>) morphology. The 5\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) for those patients with <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> expression was 80% and 59% for those without (p\u00a0&lt;\u00a00.001). The 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates for those patients with <jats:styled-content style=\"fixed-case\">HG<\/jats:styled-content> morphology and positive <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> expression was 72% and 31% for those with negative <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> expression (p\u00a0=\u00a00.044). This study suggests that the expression of <jats:styled-content style=\"fixed-case\">CA II<\/jats:styled-content> acts as independent prognostic biomarker for survival in <jats:styled-content style=\"fixed-case\">PMP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/apm.12653","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T13:01:51Z","timestamp":1487941311000},"page":"207-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Carbonic anhydrase <scp>II<\/scp>: a novel biomarker for pseudomyxoma peritonei"],"prefix":"10.1111","volume":"125","author":[{"given":"Petrus","family":"J\u00e4rvinen","sequence":"first","affiliation":[{"name":"Department of Urology Helsinki University Hospital Helsinki Finland"},{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti 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