{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:45:48Z","timestamp":1792032348869,"version":"4.4.0"},"reference-count":121,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>The use of central venous catheters (CVC) is associated with a risk of microbial colonization and subsequent potentially severe infection. Microbial contamination of the catheter leads to the development of a microbial consortia associated with the CVC surface and embedded in an extracellular matrix, named biofilm. This biofilm provides bacterial cells the ability to survive antimicrobial agents and the host immune system and to disseminate to other sites of the body. The best preventive strategy is to avoid any unnecessary catheterization or to reduce indwelling duration when a CVC is required. Beside aseptic care and antibiotic\u2010impregnated catheters (like minocycline\/rifampin), preventive locks can be proposed in some cases, whereas non\u2010biocidal approaches are under active research like anti\u2010adhesive or competitive interactions strategies. When the diagnosis of catheter\u2010related bloodstream infection (CRBSI) is suspected on clinical symptoms, it requires a microbiological confirmation by paired blood cultures in order to avoid unnecessary catheter removal. The treatment of CRBSI relies on catheter removal and systemic antimicrobials. However, antibiotic lock technique (ALT) can be used as an attempt to eradicate biofilm formed on the inside lumen of the catheter in case of uncomplicated long\u2010term catheter\u2010related BSI caused by coagulase\u2010negative staphylococci (CoNS) or <jats:italic>Enterobacteriaceae<\/jats:italic>. Recently, promising strategies have been developed to improve biofilm eradication; they rely on matrix degradation or destabilization or the development of anti\u2010persister compounds, targeting the most tolerant bacterial cells inside the biofilm. Understanding biofilm formation at the molecular level may help us to develop new approaches to prevent or treat these frequent infections.<\/jats:p>","DOI":"10.1111\/apm.12665","type":"journal-article","created":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T13:52:27Z","timestamp":1492350747000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Central venous catheters and biofilms: where do we stand in 2017?"],"prefix":"10.1111","volume":"125","author":[{"given":"Marie","family":"Gominet","sequence":"first","affiliation":[{"name":"Service de Microbiologie Unit\u00e9 Mobile de Microbiologie Clinique Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Europ\u00e9en Georges Pompidou Paris France"},{"name":"Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Compain","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Paris France"},{"name":"Service de Microbiologie Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Europ\u00e9en Georges Pompidou Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Beloin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de G\u00e9n\u00e9tique des Biofilms D\u00e9partement de Microbiologie Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lebeaux","sequence":"additional","affiliation":[{"name":"Service de Microbiologie Unit\u00e9 Mobile de Microbiologie Clinique Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Europ\u00e9en Georges Pompidou Paris France"},{"name":"Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-5-200003070-00009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_2_7_4_1","unstructured":"Enqu\u00eate nationale de pr\u00e9valence des infections nosocomiales et des traitements anti\u2010infectieux en \u00e9tablissements de sant\u00e9 France mai\u2010juin 2012\/2013\/Maladies infectieuses\/Rapports et synth\u00e8ses\/Publications et outils\/Accueil [Internet]. 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