{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:13:06Z","timestamp":1785539586320,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Norwegian Institute for Nature Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Hantaviruses pose a public health concern worldwide causing haemorrhagic fever with renal syndrome (<jats:styled-content style=\"fixed-case\">HFRS<\/jats:styled-content>) and hantavirus pulmonary syndrome (<jats:styled-content style=\"fixed-case\">HPS<\/jats:styled-content>). Puumala virus (<jats:styled-content style=\"fixed-case\">PUUV<\/jats:styled-content>) is the most prevalent hantavirus in Central and Northern Europe, and causes a mild form of <jats:styled-content style=\"fixed-case\">HFRS<\/jats:styled-content>, also known as nephropathia epidemica (<jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>). In nature, the main host of <jats:styled-content style=\"fixed-case\">PUUV<\/jats:styled-content> is the bank vole (<jats:italic>Myodes glareolus<\/jats:italic>), and transmission to humans occurs through inhalation of aerosols from rodent excreta. Nephropathia epidemica is particularly prevalent in Nordic countries, however, few studies of <jats:styled-content style=\"fixed-case\">PUUV<\/jats:styled-content> have been performed in Norway. The aim of this study was to analyse the dynamics of <jats:styled-content style=\"fixed-case\">PUUV<\/jats:styled-content> in Norway and compare with bank vole population dynamics, and also to complement the current diagnostic methodology of <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content> in Norway. Our results showed a significant seasonal and geographical variation of <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>, and a general parallel peak trend between bank vole population densities and human <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content> incidence. A real\u2010time and a nested <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> were successfully established as an invaluable diagnostic tool, with detection and sequencing of <jats:styled-content style=\"fixed-case\">PUUV<\/jats:styled-content> in a human serum sample for the first time in Norway. Phylogenetic analysis showed clustering of the obtained human sample with previous Norwegian bank vole isolates.<\/jats:p>","DOI":"10.1111\/apm.12712","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T08:52:53Z","timestamp":1496739173000},"page":"732-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circulation and diagnostics of Puumala virus in Norway: nephropatia epidemica incidence and rodent population dynamics"],"prefix":"10.1111","volume":"125","author":[{"given":"Natacha","family":"Milhano","sequence":"first","affiliation":[{"name":"Department of Virology Norwegian Institute of Public Health Domain for Environmental Health and Infectious Disease Control Oslo Norway"},{"name":"European Programme for Public Health Microbiology Training (EUPHEM) European Centre for Disease Prevention and Control (ECDC) Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Korslund","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences University of Agder Kristiansand Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Evander","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Virology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clas","family":"Ahlm","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Infectious Diseases Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsti","family":"Vainio","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Control Department of Virology Norwegian Institute of Public Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne G.","family":"Dudman","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Control Department of Virology Norwegian Institute of Public Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5shild","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Control Department of Virology Norwegian Institute of Public Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-369408-9.00023-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1722"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111663"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.10.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-016-3899-x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(03)00774-6","article-title":"Hantavirus infections in Europe","volume":"3","author":"Vapalahti O","year":"2093","journal-title":"Lancet Infect Dis"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2009.0138"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2009.03.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1501.080502"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548809032450"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-11-2603"},{"key":"e_1_2_6_13_1","unstructured":"FramstadE editor.Terrestrisk naturoverv\u00e5king i 2013: Markvegetasjon epifytter sm\u00e5gnagere og fugl \u2013 Sammenfatning av resultater. 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