{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:56:13Z","timestamp":1770512173518,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Splenosis is an acquired anomaly related to heterotopic auto\u2010transplantation of splenic tissue following abdominal trauma or splenectomy. We report the first definitive bilateral ovarian case in a 65\u2010year\u2010old woman who underwent splenectomy following a motor vehicle accident 44\u00a0years prior to presentation. We review the literature and discuss the main differential diagnoses. Gross examination revealed a 1\u2010cm well\u2010circumscribed dark nodule on the surface of each ovary. Paraffin\u2010embedded, formalin\u2010fixed blocks were sectioned and stained with hematoxylin\u2013eosin and immunostains (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>5\/6, Calretinin, <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1, Vimentin). The histological presence of both red and white splenic pulp, delimitation from ovarian tissue and ovarian origin of blood supply, as well as medical history, led us to the correct diagnosis. The outer nodular surface was covered by mesothelium (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1+, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>5\/6+, Calretinin+, Vimentin+), which was in continuity with the ovarian surface epithelium. To our knowledge, only six previous cases of ovarian splenosis are reported. Our patient is the oldest, with a very long interval from splenectomy to presentation. Clinically, splenosis may mimic malignancy, and a correct diagnosis avoids unnecessary overtreatment. The differential diagnosis includes an accessory spleen, spleno\u2010gonadal fusion, and splenic hamartoma: they should be excluded to come to the correct diagnosis.<\/jats:p>","DOI":"10.1111\/apm.12714","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:20:03Z","timestamp":1495732803000},"page":"844-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A unique case of bilateral ovarian splenosis and review of the literature"],"prefix":"10.1111","volume":"125","author":[{"given":"Maria Giulia","family":"Disanto","sequence":"first","affiliation":[{"name":"Department of Health Science School of Medicine University of Eastern Piedmont \u201cAmedeo Avogadro\u201d Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Mercalli","sequence":"additional","affiliation":[{"name":"Unit of Pathology \u201cMaggiore della Carit\u00e0\u201d Hospital Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Palicelli","sequence":"additional","affiliation":[{"name":"Department of Health Science School of Medicine University of Eastern Piedmont \u201cAmedeo Avogadro\u201d Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Arnulfo","sequence":"additional","affiliation":[{"name":"Unit of Obstetrics and Gynecology \u201cMaggiore della Carit\u00e0\u201d Hospital Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo","family":"Boldorini","sequence":"additional","affiliation":[{"name":"Department of Health Science School of Medicine University of Eastern Piedmont \u201cAmedeo Avogadro\u201d Novara Italy"},{"name":"Unit of Pathology \u201cMaggiore della Carit\u00e0\u201d Hospital Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"890602","article-title":"Splenosis: a rare etiology for bowel obstruction\u2010a case report and review of the literature","volume":"2015","author":"Younan G","year":"2015","journal-title":"Case Rep Surg"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/321810"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2011.30"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e318038d1f8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1992.tb00443.x"},{"key":"e_1_2_6_7_1","first-page":"811","article-title":"A rare case of ovarian splenosis","volume":"57","author":"Gheonea IA","year":"2016","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/472162"},{"key":"e_1_2_6_9_1","first-page":"120","article-title":"Splenosis of the peritoneal cavity resembling an adnexal tumor: case report","volume":"34","author":"Peitsidis P","year":"2007","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.026104"},{"key":"e_1_2_6_11_1","first-page":"14","article-title":"Splenosis: a report of ovarian stromal involvement","volume":"98","author":"Tawfik O","year":"1998","journal-title":"Kans Med"},{"key":"e_1_2_6_12_1","first-page":"51S","article-title":"Splenosis mimicking endometriosis","volume":"59","author":"Watson WJ","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_13_1","unstructured":"BullardPD MarkeeJE.Ovarian stromal splenosis \u2013 a case report. Paper presented at the 20th Armed Forces Seminar on Obstetrics and Gynecology Las Vegas Nevada 1971."},{"key":"e_1_2_6_14_1","volume-title":"Atlas of Nontumor Pathology, Volume 7","author":"O'Malley DP","year":"2009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.5858\/2001-125-1483-HOS","article-title":"Heterotopic ovarian splenoma: report of a first case","volume":"125","author":"Cualing H","year":"2001","journal-title":"Arch Pathol Lab Med"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:13:36Z","timestamp":1696486416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/apm.12714"],"URL":"https:\/\/doi.org\/10.1111\/apm.12714","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]},"assertion":[{"value":"2017-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}