{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:30:19Z","timestamp":1761766219657},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CLRPG8B0033","CLRPG8E0161"],"award-info":[{"award-number":["CLRPG8B0033","CLRPG8E0161"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>A recurrent <jats:italic>YAP1\u2010TFE3<\/jats:italic> gene fusion has been identified in <jats:italic>WWTR1\u2010CAMTA1<\/jats:italic>\u2010negative epithelioid hemangioendotheliomas arising in soft tissue, bone, and lung, but not in liver. We present the first case of <jats:italic>TFE3\u2010<\/jats:italic>rearranged hepatic epithelioid hemangioendothelioma in a 39\u2010year\u2010old Taiwanese woman. Computed tomography scan revealed multifocal, ill\u2010defined nodules involving both hepatic lobes. She then underwent deceased donor liver transplantation. Histologically, the tumors in the liver explant showed a biphasic growth pattern. One component was composed of dilated and well\u2010formed blood vessels lined by epithelioid cells with abundant eosinophilic cytoplasm, mimicking an alveolar pattern, whereas the other component was composed of cords and single cells, featuring intracytoplasmic vacuoles, separated by a myxoid stroma. The tumor cells showed vesicular nuclei and small indistinct nucleoli with mild to moderate cytologic atypia. Most tumor cells showed factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CD<\/jats:styled-content>34, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31, and <jats:styled-content style=\"fixed-case\">TFE<\/jats:styled-content>3 positivity in immunohistochemical study. Fluorescence <jats:italic>in situ<\/jats:italic> hybridization analysis for the tumor cells exhibited <jats:italic><jats:styled-content style=\"fixed-case\">TFE<\/jats:styled-content>3<\/jats:italic> gene rearrangement. The patient is currently alive, and no post\u2010operative tumor recurrence developed during a 13\u2010year follow\u2010up. Awareness of this rare vasoformative variant and identification of the gene rearrangement would be helpful on differential diagnosis with other high\u2010grade carcinoma and angiosarcoma of liver.<\/jats:p>","DOI":"10.1111\/apm.12716","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T08:44:42Z","timestamp":1496738682000},"page":"849-853","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>TFE3\u2010<\/i>rearranged hepatic epithelioid hemangioendothelioma\u2014a case report with immunohistochemical and molecular study"],"prefix":"10.1111","volume":"125","author":[{"given":"Fang\u2010Ying","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Pathology Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung 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