{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:55:32Z","timestamp":1791633332054,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671594"],"award-info":[{"award-number":["81671594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571591"],"award-info":[{"award-number":["81571591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,10]]},"abstract":"\n This study was aimed to evaluate levels of neutrophil\u2010 (\n NLR<\/jats:styled-content>\n ), monocyte\u2010 (\n MLR<\/jats:styled-content>\n ), eosinophil\u2010 (\n ELR<\/jats:styled-content>\n ), and basophil\u2010lymphocyte ratio (\n BLR<\/jats:styled-content>\n ) and their association with inflammatory markers in systemic autoimmune rheumatic diseases (\n SARD<\/jats:styled-content>\n s). A total of 1139\n SARD<\/jats:styled-content>\n patients and 170 healthy individuals were enrolled. Clinical and laboratory data were extracted.\n NLR<\/jats:styled-content>\n and\n MLR<\/jats:styled-content>\n were significantly increased, but\n BLR<\/jats:styled-content>\n decreased in most\n SARD<\/jats:styled-content>\n patients (p\u00a0<\u00a00.05).\n ELR<\/jats:styled-content>\n were significantly decreased in systemic lupus erythematosus (\n SLE<\/jats:styled-content>\n ) patients, but increased in those with other\n SARD<\/jats:styled-content>\n s (p\u00a0<\u00a00.001). In\n SLE<\/jats:styled-content>\n patients, C\u2010reactive protein (\n CRP<\/jats:styled-content>\n ) showed positive correlation with\n NLR<\/jats:styled-content>\n ,\n MLR<\/jats:styled-content>\n , and\n BLR<\/jats:styled-content>\n . IgG negatively correlated with\n NLR<\/jats:styled-content>\n , and did positively with\n ELR<\/jats:styled-content>\n . IgM negatively correlated with\n NLR<\/jats:styled-content>\n and\n MLR<\/jats:styled-content>\n . In those with rheumatoid arthritis (\n RA<\/jats:styled-content>\n ), ankylosing spondylitis (\n AS<\/jats:styled-content>\n ), and osteoarthritis (\n OA<\/jats:styled-content>\n ),\n NLR<\/jats:styled-content>\n and\n MLR<\/jats:styled-content>\n positively correlated with erythrocyte sedimentation rate (\n ESR<\/jats:styled-content>\n ) and\n CRP<\/jats:styled-content>\n . In primary Sj\u00f6gren's syndrome (\n pSS<\/jats:styled-content>\n ) patients,\n ESR<\/jats:styled-content>\n showed positive correlation with\n NLR<\/jats:styled-content>\n and\n MLR<\/jats:styled-content>\n . IgA had positive correlation with\n BLR<\/jats:styled-content>\n . In polymyositis\/dermatomyositis (\n PM<\/jats:styled-content>\n \/\n DM<\/jats:styled-content>\n ) patients,\n ESR<\/jats:styled-content>\n and\n CRP<\/jats:styled-content>\n positively correlated with\n NLR<\/jats:styled-content>\n . Additionally, significant correlations were also found between\n CRP<\/jats:styled-content>\n and\n BLR<\/jats:styled-content>\n , IgG and\n ELR<\/jats:styled-content>\n , IgM and\n ELR<\/jats:styled-content>\n . In systemic sclerosis (\n SS<\/jats:styled-content>\n c) patients, clear correlations were only observed between\n CRP<\/jats:styled-content>\n and\n NLR<\/jats:styled-content>\n or\n MLR<\/jats:styled-content>\n . In mixed connective tissue disease (\n MCTD<\/jats:styled-content>\n ) patients,\n NLR<\/jats:styled-content>\n positively correlated with\n ESR<\/jats:styled-content>\n and\n CRP<\/jats:styled-content>\n , while\n NLR<\/jats:styled-content>\n and\n MLR<\/jats:styled-content>\n did negatively with IgM. In polymyalgia rheumatic (\n PMR<\/jats:styled-content>\n ) patients,\n MLR<\/jats:styled-content>\n positively correlated with\n CRP<\/jats:styled-content>\n , while\n ELR<\/jats:styled-content>\n did negatively with IgG. This study demonstrated increased\n NLR<\/jats:styled-content>\n and\n MLR<\/jats:styled-content>\n and deceased\n BLR<\/jats:styled-content>\n in most\n SARD<\/jats:styled-content>\n s, decreased\n ELR<\/jats:styled-content>\n in\n SLE<\/jats:styled-content>\n and increased\n ELR<\/jats:styled-content>\n in other\n SARD<\/jats:styled-content>\n s. Furthermore,\n NLR<\/jats:styled-content>\n and\n MLR<\/jats:styled-content>\n may be useful tools to reflect inflammatory status of\n SARD<\/jats:styled-content>\n s.\n <\/jats:p>","DOI":"10.1111\/apm.12722","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T07:56:38Z","timestamp":1501660598000},"page":"863-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Comparisons of neutrophil\u2010, monocyte\u2010, eosinophil\u2010, and basophil\u2010 lymphocyte ratios among various systemic autoimmune rheumatic diseases"],"prefix":"10.1111","volume":"125","author":[{"given":"Zaixing","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Taizhou First People's Hospital, Huangyan Hospital Affiliated to Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of VIP Changzheng Hospital, Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of General Surgery Taizhou First People's Hospital Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingpeng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Taizhou First People's Hospital, Huangyan Hospital Affiliated to Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Taizhou First People's Hospital, Huangyan Hospital Affiliated to Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renqian","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics Changzheng Hospital, Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics Changzheng Hospital, Second Military Medical University Shanghai 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