{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:28:41Z","timestamp":1785540521514,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002636","name":"Inje University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> and Epstein\u2010Barr virus (EBV) infection, and associated cytokines are involved in gastric carcinogenesis. We investigated the expression of these cytokines and their relationship with clinicopathological characteristics. The study included specimens from 207 patients with gastric adenocarcinoma, 56 with chronic gastritis, 32 with metaplasia, and 30 with low\u2010grade epithelial dysplasia. Tissue microarrays were constructed and immunohistochemical staining for IL\u20101\u03b2, IL\u20106, IL\u201010, IL\u201017, p16, p21, TNF\u2010\u03b1, and <jats:styled-content style=\"fixed-case\">TNFR<\/jats:styled-content>1 was performed. <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> and <jats:italic>H. pylori<\/jats:italic> infection status was determined. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, p16, and p21 protein expression was significantly higher in adenocarcinoma cases than in the other cases (p &lt; 0.05). <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> was only noted in adenocarcinoma (13 cases, 6.3%). The <jats:italic>H. pylori<\/jats:italic> infection rate in adenocarcinoma was significantly higher than that in the other cases (p &lt; 0.005). <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 expression was associated with improved survival (p &lt; 0.05), whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 expression was associated with decreased survival (p &lt; 0.05). <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 expression was inversely associated with angioinvasion, and disease stage (p &lt; 0.05), whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 expression was associated with disease stage (p &lt; 0.05). <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 expression was correlated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 expression, and p16 expression was correlated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> status. Our results indicate that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 are associated with gastric carcinogenesis and may be considered prognostic factors.<\/jats:p>","DOI":"10.1111\/apm.12725","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T06:12:35Z","timestamp":1500876755000},"page":"808-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cytokine expression associated with <i>Helicobacter pylori<\/i> and Epstein\u2010Barr virus infection in gastric carcinogenesis"],"prefix":"10.1111","volume":"125","author":[{"given":"Jung Yeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pathology Inje University Sanggye Paik Hospital Seoul 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