{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:41:42Z","timestamp":1696581702439},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Fifteen to 50% of fetal deaths remain unexplained after post\u2010mortem examination depending on inclusion criteria and classification systems. Our aim was to examine a selection of unexplained fetal deaths in order to investigate whether any common chromosome aberrations or viral infections were present. Reports from 351 fetal autopsies performed at the Department of Pathology and Medical Genetics at St. Olavs University Hospital from 2001 through 2010 were reviewed. Of these, 105 fetal deaths were classified as unexplained. Tissue samples from 30 cases were further examined with fluorescence <jats:italic>in\u00a0situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) to detect abnormalities in chromosomes 13, 18, and 21. The samples were also examined with immunohistochemistry (<jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>) and polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) to detect infections with cytomegalovirus, parvovirus B19, herpes simplex virus 1 and 2, enterovirus, and parechovirus. In two cases, a possible trisomy 13 mosaicism was found. No viruses were detected. In our selection of 30 unexplained cases, possible trisomy 13 mosaicism was found in two cases, and no viruses were detected. High degree of maceration and missing placental examination often complicate the investigation of fetal death, and extensive ancillary examinations do not necessarily contribute to a more specific diagnosis.<\/jats:p>","DOI":"10.1111\/apm.12726","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T05:08:43Z","timestamp":1500872923000},"page":"826-832","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unrecognized viral infections and chromosome abnormalities as a cause of fetal death \u2013 examination with fluorescence <i>in\u00a0situ<\/i> hybridization, immunohistochemistry and polymerase chain reaction"],"prefix":"10.1111","volume":"125","author":[{"given":"Bente Ediassen","family":"Opsj\u00f8n","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Children's and Women's Health Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svein Arne","family":"Nordb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Children's and Women's Health Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"},{"name":"Department of Medical Microbiology St. Olavs Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Children's and Women's Health Faculty of Medicine Norwegian University of Science and Technology (NTNU) Trondheim Norway"},{"name":"Department of Pathology and Medical Genetics St. Olavs Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.098"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.05.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1823"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00371-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60064-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.11.041"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200008000-00024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00882.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2759"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100249910032"},{"key":"e_1_2_7_12_1","first-page":"141","article-title":"Fluorescence in\u00a0situ hybridisation on formalin fixed fetal tissue in the diagnosis of chromosomal syndromes","volume":"5","author":"Cobben JM","year":"1994","journal-title":"Genet Couns"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.940"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir121"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020701813792"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.12.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2008.02.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01600280"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2350\/15-03-1614-OA.1"},{"key":"e_1_2_7_21_1","first-page":"2533","article-title":"A rapid and simplified technique for analysis of archival formalin\u2010fixed, paraffin\u2010embedded tissue by fluorescence in\u00a0situ hybridization (FISH)","volume":"16","author":"K\u00f6pf I","year":"1996","journal-title":"Anticancer Res"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2058-2064.2005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(00)00292-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.11.4006-4009.2000"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1505.081286"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.04.007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu016"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139237017.005"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980901)79:2<121::AID-AJMG8>3.0.CO;2-T"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.3.175"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2016.07.010"},{"key":"e_1_2_7_32_1","first-page":"1","article-title":"The introduction of the absolute risk for the detection of fetal aneuploidies in the first\u2010trimester screening","author":"Padula F","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23757"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.02.002"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.02.004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21293"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.09.013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3835"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2009.027"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201569"}],"container-title":["APMIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapm.12726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apm.12726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:12:45Z","timestamp":1696486365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apm.12726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/apm.12726"],"URL":"https:\/\/doi.org\/10.1111\/apm.12726","archive":["Portico"],"relation":{},"ISSN":["0903-4641","1600-0463"],"issn-type":[{"value":"0903-4641","type":"print"},{"value":"1600-0463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]},"assertion":[{"value":"2017-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}