{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:53:42Z","timestamp":1779296022835,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Research Fund of Xiamen Municipal Planning Commission","award":["3502Z20149015"],"award-info":[{"award-number":["3502Z20149015"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Metal wear debris has been shown to activate an aseptic osteolytic process that causes failure in total joint arthroplasty (<jats:styled-content style=\"fixed-case\">TJA<\/jats:styled-content>). This osteolysis is characterized by a proinflammatory, self\u2010propagating immune response involving primarily macrophages, dendritic cells, and activated osteoclasts, as well as T cells and B cells. The human bone morphogenic protein (<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>)\u20107, on the other hand, was shown to promote osteoblast survival, and reversed the downregulation of anabolic Smad proteins and Runx2 following cobalt injury. Therefore, we investigated the effect and mechanism of <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20107 on the proinflammatory immune responses in osteoarthritis patients with previous <jats:styled-content style=\"fixed-case\">TJA<\/jats:styled-content>. Cobalt\u2010treated monocytes\/macrophages presented significantly elevated levels of interleukin 6 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) and tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>), both of which were suppressed by the addition of exogenous <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20107. In patients with <jats:styled-content style=\"fixed-case\">TJA<\/jats:styled-content>, the serum <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20107 level was inversely associated with the level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> secreted by monocytes\/macrophages. Cobalt\u2010treated monocytes\/macrophages effectively supported Th17 inflammation, by an <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106\u2010dependent but not <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010dependent mechanism. <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20107, however, significantly suppressed cobalt\u2010induced Th17 inflammation. In patients with <jats:styled-content style=\"fixed-case\">TJA<\/jats:styled-content>, the risk of osteolysis development was positively associated with the frequency of Th17 cells and negatively associated with the level of <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20107. Together, these results demonstrated that <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20107 could serve as a therapeutic agent in treating patients with metal wear debris\u2010induced inflammation.<\/jats:p>","DOI":"10.1111\/apm.12730","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T06:23:03Z","timestamp":1500877383000},"page":"880-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>BMP<\/scp>\u20107 ameliorates cobalt alloy particle\u2010induced inflammation by suppressing Th17 responses"],"prefix":"10.1111","volume":"125","author":[{"given":"Fengrong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedics Chenggong Hospital Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruisong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chenggong Hospital Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chenggong Hospital Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chenggong Hospital Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chenggong Hospital Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chenggong Hospital Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojian","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chenggong Hospital Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.5.3.383"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000198004.88568.96"},{"key":"e_1_2_7_4_1","first-page":"S234","article-title":"Mediators of the inflammatory response to joint replacement devices","volume":"20","author":"Cobelli N","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.04.035"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158398"},{"key":"e_1_2_7_7_1","first-page":"111","article-title":"Pathophysiological aspects of hip implants","volume":"15","author":"Sargeant A","year":"2006","journal-title":"J Surg Orthop Adv"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0753"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.09.023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21199"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B3.23281"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.C.00949"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200112000-00007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190412331279890"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.15.4132"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-007-0422-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00103.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147897"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/y2012-102"},{"key":"e_1_2_7_20_1","first-page":"22175","article-title":"Therapeutic effects of OP\u20101 on metal wear particle induced osteoblasts injury in\u00a0vitro","volume":"8","author":"Sun G","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1496"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040391"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-378653"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0816-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002615"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27622"},{"key":"e_1_2_7_27_1","first-page":"295","article-title":"Breaking old paradigms: Th17 cells in autoimmune arthritis. 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