{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:32:15Z","timestamp":1756996335946},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>To analyze the expression trends and clinical significance of Apurinic\/Apyrimidinic Endodeoxyribonuclease 1 (<jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101) and Nucleophosmin (<jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1) proteins in high\u2010grade serous ovarian adenocarcinoma (<jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>). The expressions of <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101 and <jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1 proteins in 94 patients with <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> were determined using the immunohistochemical (<jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>) method, and their relationships with clinicopathological features were analyzed by the \u03c7<jats:sup>2<\/jats:sup> test or Fisher's exact test. The follow\u2010up data, Cox proportional hazards univariate and multivariate survival analyses were integrated to evaluate the prognostic factors affecting patients with <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>. In the normal fallopian tubes, <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101 and <jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1 protein were mainly distributed in the nuclear. The <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> experienced changes in the cellular localization of <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101 and <jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1 protein expressions, which were abnormally expressed in the cytoplasm. The rates of abnormal cytoplasmic expression of <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101 and <jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1 proteins in 94 patients with <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> were 69.1% and 73.4%, respectively, which were significantly higher than the normal fallopian tube tissues (p &lt; 0.05). The abnormal cytoplasmic <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101 and <jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1 are significantly correlated with the lymph node metastasis, chemosensitivity, <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> staging, and prognosis. The <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content> multivariate survival analysis showed that the abnormal expression of <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101 protein, <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content> staging, and lymph node metastasis are independent prognostic factors. Collectively, the abnormal cytoplasmic <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>1\/Ref\u20101 and <jats:styled-content style=\"fixed-case\">NPM<\/jats:styled-content>1 proteins are associated with the oncogenic progression and chemoresistance of <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>, and predict a poor prognosis.<\/jats:p>","DOI":"10.1111\/apm.12733","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T11:32:38Z","timestamp":1501673558000},"page":"857-862","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The expression profile and prognostic value of <scp>APE<\/scp>\/Ref\u20101 and <scp>NPM<\/scp>1 in high\u2010grade serous ovarian adenocarcinoma"],"prefix":"10.1111","volume":"125","author":[{"given":"Xiaomei","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology The Fourth Hospital 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