{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:57:33Z","timestamp":1788872253957,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012446","name":"Ahus","doi-asserted-by":"crossref","award":["No 2649027"],"award-info":[{"award-number":["No 2649027"]}],"id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Staphylococcus aureus<\/jats:italic> bloodstream infections (SABSI) are associated with high morbidity and mortality. The Toll\u2010like receptor 2 (TLR2) and Toll\u2010interacting protein (TOLLIP) are important in recognition and regulation of human innate immunity response to S. aureus<\/jats:italic>. Single nucleotide polymorphisms (SNP<\/jats:styled-content>s) in the TLR<\/jats:styled-content>2 and TOLLIP<\/jats:styled-content> encoding genes have been associated with disease, including BSI<\/jats:styled-content>. The aim of this study was to examine potential associations between a selection of SNP<\/jats:styled-content>s in the genes encoding TLR<\/jats:styled-content>2 and TOLLIP<\/jats:styled-content>, and predisposition, severity, and outcome of SABSI<\/jats:styled-content>. All patients \u226518 years of age with at least one S. aureus<\/jats:italic> positive blood culture collected from March 2011 through February 2014 at Akershus University Hospital, L\u00f8renskog, Norway, were considered for inclusion. Patients attending elective orthopaedic surgery (total hip and knee replacements, lumbar surgery) served as a control group. The TLR<\/jats:styled-content>2 Arg753Gln, TLR<\/jats:styled-content>2 Pro631His, TOLLIP<\/jats:styled-content> rs5743942, and rs5743867 polymorphisms were analysed using TaqMan SNP<\/jats:styled-content> Genotyping Assays. A total of 209 SABSI<\/jats:styled-content> patients and 295 controls were included. The TLR<\/jats:styled-content>2 Arg753Gln and TLR<\/jats:styled-content>2 Pro631His polymorphisms were infrequent with no homozygotes and <10% heterozygotes. The included TLR<\/jats:styled-content>2 and TOLLIP<\/jats:styled-content> polymorphisms were not associated with susceptibility to SABSI<\/jats:styled-content>, severity, 30\u2010day all\u2010cause mortality, or SABSI<\/jats:styled-content> caused by the clonal complex 30 (CC<\/jats:styled-content>30) genotype.<\/jats:p>","DOI":"10.1111\/apm.12734","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T07:26:48Z","timestamp":1500881208000},"page":"927-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["No associations established between single nucleotide polymorphisms in human Toll\u2010like receptor 2 and Toll\u2010interacting protein and Staphylococcus aureus<\/i> bloodstream infections"],"prefix":"10.1111","volume":"125","author":[{"given":"Tom Eirik","family":"Smeland","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine and Biosciences Department of 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